EP 0722446 A1 19960724 - DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS
Title (en)
DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS
Title (de)
DISTAMYCIN A ANALOGA ALS ANTITUMOR- ODER ANTIVIRALE WIRKSTOFFE
Title (fr)
ANALOGUES DE LA DISTAMYCINE UTILES EN TANT QU'AGENTS ANTITUMORAUX OU ANTIVIRAUX
Publication
Application
Priority
- EP 9502814 W 19950718
- GB 9416005 A 19940808
Abstract (en)
[origin: WO9605196A1] The present invention relates to compounds of formula (I) wherein n is 0 or 1; each of X, Y, Z is independently N or CH; A is a pentatomic heteromonocyclic ring unsubstituted or substituted by a C1-C3 alkyl group; B is (a); (b); (c) or (d); and either R1 and R2 are the same and they are both a C1-C6 alkyl group unsubstituted or substituted by halogen or hydroxy; or one of R1 and R2 is hydrogen and the other is a group (e) in which m is zero or an integer of 1 to 4 and R4 is aziridinyl; cyclopropyl; a vinyl group unsubstituted or substituted in position 1 or 2 by halogen or C1-C3 alkyl; an oxyranyl group unsubstituted or substituted in position 2 by a C1-C3 alkyl or halogen; or a group (f) in which R5 and R6 are both a C1-C6 alkyl group unsubstituted or substituted by a halogen or hydroxy; provided that: a) when each of X, Y, Z is CH, then A is not thiophene or pyrrole unsubstituted or substituted by a C1-C3 alkyl group; and b) when n is 1, each of X, Y, Z is CH and R1 and R2 are the same and they are both 2-chloroethyl, then A is not 1-methylimidazole or thiazole; and the pharmaceutically acceptable salt thereof. The compounds of the invention are useful as antitumor or antiviral agents.
IPC 1-7
IPC 8 full level
C07D 231/40 (2006.01); A61K 31/41 (2006.01); A61K 31/415 (2006.01); A61K 31/425 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07D 231/38 (2006.01); C07D 403/14 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP KR US)
A61K 31/40 (2013.01 - KR); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07D 231/38 (2013.01 - EP US); C07D 403/14 (2013.01 - EP KR US); C07D 417/14 (2013.01 - EP US)
Citation (search report)
See references of WO 9605196A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9605196 A1 19960222; AT E229524 T1 20021215; AU 3113695 A 19960307; AU 689623 B2 19980402; CA 2172629 A1 19960222; CN 1131946 A 19960925; DE 69529143 D1 20030123; DE 69529143 T2 20030911; EP 0722446 A1 19960724; EP 0722446 B1 20021211; ES 2188666 T3 20030701; FI 961506 A0 19960403; FI 961506 A 19960605; GB 9416005 D0 19940928; HU 9601218 D0 19960729; HU T76267 A 19970728; IL 114794 A0 19951208; JP H09504039 A 19970422; KR 960704884 A 19961009; MX 9601250 A 19981231; NO 961377 D0 19960403; NO 961377 L 19960530; NZ 290404 A 19970424; PL 313821 A1 19960722; US 5753629 A 19980519; ZA 956590 B 19960318
DOCDB simple family (application)
EP 9502814 W 19950718; AT 95926927 T 19950718; AU 3113695 A 19950718; CA 2172629 A 19950718; CN 95190742 A 19950718; DE 69529143 T 19950718; EP 95926927 A 19950718; ES 95926927 T 19950718; FI 961506 A 19960403; GB 9416005 A 19940808; HU 9601218 A 19950718; IL 11479495 A 19950801; JP 50694595 A 19950718; KR 19960701819 A 19960408; MX 9601250 A 19960401; NO 961377 A 19960403; NZ 29040495 A 19950718; PL 31382195 A 19950718; US 61283696 A 19960318; ZA 956590 A 19950807