EP 0722738 A2 19960724 - Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
Title (en)
Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
Title (de)
Impfung und Verfahren gegen Krankheiten, die von pathologischen Reaktionen durch spezifischen T-Zellpopulation abstammen
Title (fr)
Vaccination et procédés contre des maladies issues de réponses pathogènes par des populations spécifiques de cellules T
Publication
Application
Priority
- EP 92904843 A 19920121
- US 64461191 A 19910122
Abstract (en)
The present invention provides vaccines and a means of vaccinating a vertebrate so as to prevent or control specific T cell mediated pathologies, including autoimmune diseases and the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragment thereof corresponding to a TCR present on the surface of T cells mediating the pathology. The vaccine fragment can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said pathology. Such a peptide can bind to conventional antigens complexed to MHC antigen presenting cells or to superantigens. Means of determining appropriate amino acid sequences for such vaccines are also provided. The vaccine is administered to the vertebrate in a manner that induces an immune response directed against the TCR of T cells mediating the pathology. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. The invention additionally provides specific beta -chain variable regions of T cell receptors, designated V beta 3, V beta 4, V beta 14 and V beta 17, which are associated with the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and multiple sclerosis (MS). Also provided are means to detect, prevent and treat RA and MS. Methods of administering DNA or RNA encoding the polypeptides useful as vaccines of the present invention into the tissue cells of an individual is also provided. <IMAGE>
IPC 1-7
A61K 39/00; A61K 39/395; A61K 47/48; A61K 48/00; G01N 33/569
IPC 8 full level
A61K 39/00 (2006.01); A61K 38/00 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07K 7/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/46 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/42 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61P 25/00 (2018.01); A61P 29/00 (2018.01); A61P 37/00 (2018.01); C07K 14/7051 (2013.01); C07K 16/2809 (2013.01); C07K 16/4258 (2013.01); A61K 39/00 (2013.01); A61K 48/00 (2013.01); A61K 2039/53 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9212996 A2 19920806; WO 9212996 A3 19921210; AU 1271692 A 19920827; AU 694062 B2 19980709; AU 7032796 A 19970116; CA 2101065 A1 19920723; EP 0568623 A1 19931110; EP 0722738 A2 19960724; EP 0722738 A3 19961023; JP 2001097886 A 20010410; JP H06507384 A 19940825; NO 932631 D0 19930721; NO 932631 L 19930921
DOCDB simple family (application)
US 9200482 W 19920121; AU 1271692 A 19920121; AU 7032796 A 19961021; CA 2101065 A 19920121; EP 92904843 A 19920121; EP 95250317 A 19920121; JP 2000259986 A 20000829; JP 50539792 A 19920121; NO 932631 A 19930721