EP 0723460 A1 19960731 - GENE THERAPY OF THE NERVOUS SYSTEM
Title (en)
GENE THERAPY OF THE NERVOUS SYSTEM
Title (de)
GENTHERAPIE FÜR DAS NERVENSYSTEMS
Title (fr)
THERAPIE GENIQUE CONCERNANT LE SYSTEME NERVEUX
Publication
Application
Priority
- US 9410977 W 19940928
- US 13108593 A 19931001
Abstract (en)
[origin: WO9509654A1] A method of treating an adverse condition of the nervous system in a chordate host (preferably a mammalian host) comprising administering to the cerebrospinal fluid of the host an expression vehicle capable of transducing a cell in order to express a therapeutic agent in the nervous system. The expression vehicle includes a nucleic acid sequence encoding a therapeutic agent for treating an adverse condition of the nervous system, and is administered in an amount effective in treating the adverse condition of the nervous system. The method of the present invention is particularly applicable to the treatment of meningeal carcinomatosis, wherein producer cells containing a retroviral vector including a gene encoding a negative selective marker (such as Herpes Simplex thymidine kinase) are administered to the cerebrospinal fluid of a patient. Such producer cells generate viral particles which transduce the meningeal carcinomatosis cells. The transduced meningeal carcinomatosis cells then are killed upon administration of an interaction agent (such as ganciclovir) which interacts with the negative selective marker.
IPC 1-7
A61K 48/00; C12N 15/86; C12N 5/22; C12N 5/16; C12N 15/52; C12N 15/38
IPC 8 full level
A61K 31/70 (2006.01); A61K 35/76 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01); C07K 14/535 (2006.01); C12N 15/861 (2006.01); C12N 15/867 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 48/00 (2013.01); A61P 25/00 (2017.12); A61P 35/00 (2017.12); C07K 14/535 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2740/13043 (2013.01); C12N 2830/008 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9509654 A1 19950413; CA 2171109 A1 19950413; EP 0723460 A1 19960731; EP 0723460 A4 19980930; JP H09505561 A 19970603
DOCDB simple family (application)
US 9410977 W 19940928; CA 2171109 A 19940928; EP 94930498 A 19940928; JP 51088195 A 19940928