EP 0725825 B1 20010221 - PEPTIDES THAT ELICIT NEUTRALIZING ANTIBODIES AGAINST GENETICALLY DIVERGENT HIV-1 STRAINS
Title (en)
PEPTIDES THAT ELICIT NEUTRALIZING ANTIBODIES AGAINST GENETICALLY DIVERGENT HIV-1 STRAINS
Title (de)
PEPTIDE, DIE NEUTRALISIERENDE ANTIKÖRPER GEGEN GENETISCH DIVERGIERENDE HIV-1 STÄMME, INDUZIEREN
Title (fr)
PEPTIDES QUI PRODUISENT DES ANTICORPS NEUTRALISANTS CONTRE DES SOUCHES DE VIH-1 GENETIQUEMENT DIVERGENTES
Publication
Application
Priority
- EP 94927602 A 19940912
- EP 9403039 W 19940912
- EP 93114631 A 19930911
Abstract (en)
[origin: WO9507354A1] Peptides are described which elicit antibodies, preferably including secretory antibodies secreted by mucosal surfaces, that show neutralizing activity against different strains and clinical isolates of HIV-1 and that inhibit the fusion of cells caused by HIV-1, which peptides are composed of a sequence of seven or eight amino acids corresponding to the ones on gp41 of gp160 of the HIV isolate BH10 at the position 662 to 668 (ELDKWAS) or at the position 661 to 668 (LELDKWAS) respectively, preferably including peptides being composed of the sequence ELDNWAS, ELNKWAS, LELDNWAS or LELNKWAS, or that are genetically encoded by nucleotide sequences corresponding to said amino acid sequences, or by sequences hybridizing to said nucleotide sequences, or by sequences deduced from said nucleotide sequences by degeneration. Preferably, the peptides substitute one or more parts of the amino acid sequence of a viral protein or are inserted into antigenic sites of a viral protein, e.g. by fusion of the respective nucleotide sequences, and subsequent expression of the fusion genes is carried out in a biological expression system.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/04 (2006.01); A61K 39/21 (2006.01); A61K 39/395 (2006.01); A61P 31/12 (2006.01); C07K 4/00 (2006.01); C07K 7/06 (2006.01); C07K 14/16 (2006.01); C07K 16/10 (2006.01); C12N 7/00 (2006.01); C12N 15/48 (2006.01); C12N 15/86 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); A61K 31/14 (2006.01); A61K 39/00 (2006.01); C12R 1/92 (2006.01)
CPC (source: EP)
A61P 31/12 (2018.01); A61P 31/18 (2018.01); A61P 37/04 (2018.01); C07K 14/005 (2013.01); A61K 39/00 (2013.01); C12N 2740/16122 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9507354 A1 19950316; AT E199260 T1 20010315; AU 682893 B2 19971023; AU 7696594 A 19950327; BR 9407531 A 19970826; CA 2171544 A1 19950316; CA 2171544 C 20030624; CN 1135237 A 19961106; CZ 287808 B6 20010214; CZ 74196 A3 19960717; DE 69426725 D1 20010329; DE 69426725 T2 20010906; EP 0725825 A1 19960814; EP 0725825 B1 20010221; ES 2156902 T3 20010801; HU 219507 B 20010428; HU 9600587 D0 19960528; HU T76102 A 19970630; JP H09502348 A 19970311; PT 725825 E 20010830; RU 2181379 C2 20020420; UA 43350 C2 20011217
DOCDB simple family (application)
EP 9403039 W 19940912; AT 94927602 T 19940912; AU 7696594 A 19940912; BR 9407531 A 19940912; CA 2171544 A 19940912; CN 94194035 A 19940912; CZ 74196 A 19940912; DE 69426725 T 19940912; EP 94927602 A 19940912; ES 94927602 T 19940912; HU 9600587 A 19940912; JP 50847395 A 19940912; PT 94927602 T 19940912; RU 96108781 A 19940912; UA 96030897 A 19940912