Global Patent Index - EP 0726777 A4

EP 0726777 A4 20020424 - PROKARYOTIC EXPRESSION OF MHC PROTEINS

Title (en)

PROKARYOTIC EXPRESSION OF MHC PROTEINS

Title (de)

Procarciotische Expression von MHC - Proteinen

Title (fr)

EXPRESSION PROCARYOTE DE PROTEINES DU CMH

Publication

EP 0726777 A4 20020424 (EN)

Application

EP 94932028 A 19941025

Priority

  • US 9412231 W 19941025
  • US 14357593 A 19931025

Abstract (en)

[origin: WO9511702A1] The present invention is directed to unglycosylated, prokaryotically-expressed MHC polypeptides, methods of producing these polypeptides, and complexes consisting essentially of an isolated MHC component and an antigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating deleterious immune responses, such as autoimmunity.

IPC 1-7

A61K 39/385; C12N 15/12; C12N 15/70; C07K 1/14; C07K 14/74; C07K 14/705

IPC 8 full level

C12N 15/09 (2006.01); A61K 9/127 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07K 14/74 (2006.01); C12N 1/21 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP KR)

A61K 39/385 (2013.01 - KR); A61P 25/00 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/70539 (2013.01 - EP); A61K 38/00 (2013.01 - EP)

Citation (search report)

  • [X] WO 9218150 A1 19921029 - ANERGEN INC [US]
  • [X] ALTMAN JOHN D ET AL: "Reconstitution of specific peptide binding and T cell recognition of class II I-E-k heterodimers from subunits produced in Escherichia coli.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, no. 17 PART C, 1993, Keystone Symposium on Emerging Principles for Vaccine Development: Antigen Processing and Presentations;Taos, New Mexico, USA; February 8-14, 1993, pages 89, XP001056801, ISSN: 0733-1959
  • [X] PARKER K C ET AL: "AN HLA-A2/BETA2-MICROGLOBULIN/PEPTIDE COMPLEX ASSEMBLED FROM SUBUNITS EXPRESSED SEPARATELY IN ESCHERICHIA COLI", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 29, no. 3, March 1992 (1992-03-01), pages 371 - 378, XP000876800, ISSN: 0161-5890
  • [X] GARBOCZI D N ET AL: "HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, no. 9, 15 April 1992 (1992-04-15), pages 3429 - 3433, XP002131059, ISSN: 0027-8424
  • [X] GODEAU F ET AL: "PURIFICATION AND LIGAND BINDING OF A SOLUBLE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE CONSISTING OF THE FIRST THREE DOMAINS OF H-2KD FUSED TO BETA2-MICROGLOBULIN EXPRESSED IN THE BACULOVIRUS-INSECT CELL SYSTEM", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 267, no. 34, 5 December 1992 (1992-12-05), pages 24223 - 24229, XP002051156, ISSN: 0021-9258
  • [PX] ALTMAN JOHN D ET AL: "Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 21, November 1993 (1993-11-01), 1993, pages 10330 - 10334, XP002190823, ISSN: 0027-8424
  • See references of WO 9511702A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9511702 A1 19950504; CA 2175089 A1 19950504; EP 0726777 A1 19960821; EP 0726777 A4 20020424; JP H09504432 A 19970506; KR 100369286 B1 20030723; KR 960705583 A 19961108

DOCDB simple family (application)

US 9412231 W 19941025; CA 2175089 A 19941025; EP 94932028 A 19941025; JP 51278094 A 19941025; KR 19960702120 A 19960425