EP 0726904 A1 19960821 - 5-FLUOROURACIL DERIVATIVES
Title (en)
5-FLUOROURACIL DERIVATIVES
Title (de)
5-FLUOROURACIL DERIVATE
Title (fr)
DERIVES DE 5-FLUORO-URACILE
Publication
Application
Priority
- GB 9402428 W 19941104
- GB 9322795 A 19931105
Abstract (en)
[origin: WO9512606A1] Novel compounds of formula (I): X-L-Y, (II): X-(L-Y)n and (III): X-L-(Y)n wherein X is a uracil reductase inactivator or prodrug thereof, Y is 5-fluorouracil or a prodrug thereof, L is a linking group covalently linked to both X and Y and n is at least 2, the use of such compounds in medicine, in particular cancer chemotherapy, pharmaceutical compositions comprising such compounds, and a process for the preparation of such compounds are disclosed.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 31/7042 (2006.01); A61K 31/7052 (2006.01); A61K 31/7064 (2006.01); A61K 31/7072 (2006.01); A61P 35/00 (2006.01); C07D 239/54 (2006.01); C07D 239/553 (2006.01); C07H 19/06 (2006.01); C07H 21/00 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); C07D 239/54 (2013.01 - EP US); C07D 239/553 (2013.01 - EP US); C07H 19/06 (2013.01 - EP US); C07H 21/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9512606A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9512606 A1 19950511; AU 8066194 A 19950523; EP 0726904 A1 19960821; GB 9322795 D0 19931222; JP H09504541 A 19970506; US 5843917 A 19981201
DOCDB simple family (application)
GB 9402428 W 19941104; AU 8066194 A 19941104; EP 94931663 A 19941104; GB 9322795 A 19931105; JP 51310095 A 19941104; US 61291196 A 19960502