EP 0728004 A1 19960828 - USE OF STEROIDS WITH A PHENOLIC A-RING STRUCTURE FOR PROPHYLAXIS AND THERAPY OF RADICAL-MEDIATED CELL DAMAGE
Title (en)
USE OF STEROIDS WITH A PHENOLIC A-RING STRUCTURE FOR PROPHYLAXIS AND THERAPY OF RADICAL-MEDIATED CELL DAMAGE
Title (de)
VERWENDUNG VON STEROIDEN MIT PHENOLISCHER A-RING-STRUKTUR ZUR PROPHYLAXE UND THERAPIE RADIKALVERMITTELTER ZELLSCHÄDIGUNGEN
Title (fr)
UTILISATION DE STEROIDES DE STRUCTURE PHENOLIQUE A CYCLE A DANS LA PROPHYLAXIE ET LE TRAITEMENT DES LESIONS CELLULAIRES INDUITES PAR DES RADICAUX
Publication
Application
Priority
- DE 9401309 W 19941108
- DE 4338314 A 19931110
Abstract (en)
[origin: WO9513076A1] The present invention pertains to new pharmaceutical preparations for prophylaxis and therapy of radical-mediated cell damage, consisting of steroids with phenolic A-ring structure-except the esterogens estradiol, estrone, estrione and their 2-hydroxy derivates as well as the steroids with cyclic substituents or with an amino group at the terminal C atom of the aliphatic C-17 side chain-and of pharmaceutical adjuvants. These preparations are characterized by a high-level inhibiting action against cell and tissue changes, such as lipid peroxidation and the oxidation of low density lipoprotein (LPL) cholesterol, caused by reactive oxygen species (ROS), free oxygen radicals and other forms of radical; these preparations thus prevent irreversible membrane and endothelial damage resulting therefrom. They therefore contribute to improving the prophylaxis and therapy of radical-induced damage such as that caused by oxygen radicals and/or ROS.
IPC 1-7
IPC 8 full level
A61K 31/565 (2006.01); A61K 31/575 (2006.01); C07J 1/00 (2006.01)
CPC (source: EP US)
A61K 31/565 (2013.01 - EP US); A61K 31/575 (2013.01 - EP US)
Citation (search report)
See references of WO 9513076A1
Designated contracting state (EPC)
AT BE CH DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 4338314 C1 19950330; AU 8104194 A 19950529; CA 2176370 A1 19950518; CA 2176370 C 19990622; EP 0728004 A1 19960828; JP 2845625 B2 19990113; JP H09507470 A 19970729; US 6172056 B1 20010109; WO 9513076 A1 19950518
DOCDB simple family (application)
DE 4338314 A 19931110; AU 8104194 A 19941108; CA 2176370 A 19941108; DE 9401309 W 19941108; EP 95900068 A 19941108; JP 51352795 A 19941108; US 64634196 A 19960509