Global Patent Index - EP 0729472 A4

EP 0729472 A4 19970319 - PIPERIDINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS

Title (en)

PIPERIDINYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS

Title (de)

PIPERIDINYLKAMPFERSULFONYLE ALS OXYTOCIN-ANTAGONISTEN

Title (fr)

ANTAGONISTES DE L'OXYTOCINE COMPRENANT DU PIPERIDINYLCAMPHOSULFONYLE

Publication

EP 0729472 A4 19970319 (EN)

Application

EP 95902668 A 19941116

Priority

  • US 9413483 W 19941116
  • US 15352193 A 19931116

Abstract (en)

[origin: WO9514025A1] Spirocyclic compounds of formula (I), where m is an integer from zero to one; Y is CH or CH2; and X is C=O, CH2, PO2H, PO2Z, where Z is C1-10 alkyl, SO2, CONH, or SO2NH. Such compounds are useful as oxytocin and vasopressin receptor antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.

IPC 1-7

C07F 9/36; C07D 221/20; C07D 227/12; C07D 227/087; C07D 401/12; C07D 401/14; A61K 31/445; A61K 31/675

IPC 8 full level

A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/445 (2006.01); A61K 31/55 (2006.01); A61K 31/66 (2006.01); A61P 7/02 (2006.01); A61P 9/12 (2006.01); A61P 13/02 (2006.01); A61P 15/00 (2006.01); A61P 43/00 (2006.01); C07D 221/20 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07F 9/576 (2006.01); C07F 9/59 (2006.01)

CPC (source: EP)

A61P 7/02 (2017.12); A61P 9/12 (2017.12); A61P 13/02 (2017.12); A61P 15/00 (2017.12); A61P 43/00 (2017.12); C07D 221/20 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07F 9/5765 (2013.01)

Citation (search report)

  • No further relevant documents disclosed
  • See references of WO 9514025A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9514025 A1 19950526; AU 1185295 A 19950606; AU 687953 B2 19980305; CA 2174650 A1 19950526; EP 0729472 A1 19960904; EP 0729472 A4 19970319; JP H09505310 A 19970527

DOCDB simple family (application)

US 9413483 W 19941116; AU 1185295 A 19941116; CA 2174650 A 19941116; EP 95902668 A 19941116; JP 51466895 A 19941116