EP 0730760 A1 19960911 - POTENTIOMETRIC BIOSENSORS, CONTROL AND APPLICATIONS THEREOF
Title (en)
POTENTIOMETRIC BIOSENSORS, CONTROL AND APPLICATIONS THEREOF
Title (de)
POTENTIOMETRISCHER BIOSENSOR,REGELUNG UND ANWENDUNG
Title (fr)
BIOCAPTEURS POTENTIOMETRIQUES, SYSTEME DE COMMANDE DE CES DERNIERS ET LEURS APPLICATIONS
Publication
Application
Priority
- GB 9324258 A 19931125
- GB 9411059 A 19940602
- GB 9411072 A 19940602
- GB 9414189 A 19940714
- IB 9400408 W 19941125
- IT RM930846 A 19931222
Abstract (en)
[origin: WO9514962A1] The present invention relates generally to a potentiometric alternating biosensor system (PAB) which can use a silicon based light-addressable transducer to measure parameters such as pH and redox potential. A first aspect relates to temperature control of a PAB system. A second aspect relates to a biosensor for measuring pH and/or redox potential variations in enzymic reactions associated with cells. A third aspect relates to a silicon transducer redox potential biosensor having deposited thereon a metal layer over at least a portion of the surface, and its use in a PAB to monitor enzymes catalyzing redox reactions. A fourth aspect relates to a 2D PAB system capable of simultaneous pH and redox potential measurement. A fifth aspect relates to use of a PAB system for measurement of extracellular acidification to monitor cell metabolism and its use for testing anti-cancer activity/toxicity of compounds on cells. A sixth aspect relates to a PAB system capable of acting as an immunosensor in an immunoassay by virtue of the application to the transducer of an immobilized monolayer of an enzyme.
IPC 1-7
IPC 8 full level
C12Q 1/00 (2006.01); G01N 33/543 (2006.01); G05D 23/20 (2006.01)
CPC (source: EP)
C12Q 1/001 (2013.01); G01N 33/54373 (2013.01); G05D 23/1919 (2013.01); G05D 23/20 (2013.01)
Citation (search report)
See references of WO 9514962A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9514962 A1 19950601; AU 1075395 A 19950613; EP 0730760 A1 19960911
DOCDB simple family (application)
IB 9400408 W 19941125; AU 1075395 A 19941125; EP 95901567 A 19941125