EP 0735889 A1 19961009 - A NOVEL TUMOR SUPPRESSOR GENE
Title (en)
A NOVEL TUMOR SUPPRESSOR GENE
Title (de)
NEUES TUMOR-SUPPRESSOR-GEN
Title (fr)
NOUVEAU GENE SUPPRESSEUR DE TUMEUR
Publication
Application
Priority
- US 9414813 W 19941220
- US 17058693 A 19931220
Abstract (en)
[origin: WO9517198A1] This invention is an isolated and purified DNA sequence encoding an Rb binding protein comprising a subsequence having at least 60% homology with nine tetratricopeptide repeats at the C-terminal end, with the proviso that the sequence encodes for neither <u>S. pombe</u> yeast protein nuc2, <u>Aspergillus nidulans</u> protein bimA, nor <u>S. cerevisiae</u> yeast protein CDC27, vectors containing said DNA, DNA probes based on said DNA, and methods of therapy utilizing said DNA and vectors. This invention is also directed to proteins encoded by said DNA, methods of therapy utilizing said proteins, and methods of expressing said proteins. Finally, this invention is directed to antibodies to said proteins, hybridomas producing said monoclonal antibodies, and diagnostic methods utilizing said antibodies.
IPC 1-7
A61K 31/70; A61K 38/17; C07H 21/04; C07K 14/00; C07K 16/18; C12N 5/06; C12N 5/12; C12N 15/00; C12P 21/00; C12Q 1/68; G01N 33/53
IPC 8 full level
A61K 31/70 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07H 21/04 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/47 (2013.01); C07K 14/4736 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9517198 A1 19950629; AU 1517495 A 19950710; BR 9408357 A 19970826; CA 2178745 A1 19950629; CN 1138295 A 19961218; CZ 178396 A3 19970312; EP 0735889 A1 19961009; EP 0735889 A4 19990414; FI 962558 A0 19960619; FI 962558 A 19960619; HU 9601686 D0 19960828; HU T74413 A 19961230; JP H09510343 A 19971021; NO 962596 D0 19960619; NO 962596 L 19960819; NZ 278745 A 19970922; PL 315172 A1 19961014; SK 76896 A3 19970205
DOCDB simple family (application)
US 9414813 W 19941220; AU 1517495 A 19941220; BR 9408357 A 19941220; CA 2178745 A 19941220; CN 94194569 A 19941220; CZ 178396 A 19941220; EP 95906694 A 19941220; FI 962558 A 19960619; HU 9601686 A 19941220; JP 51760895 A 19941220; NO 962596 A 19960619; NZ 27874594 A 19941220; PL 31517294 A 19941220; SK 76896 A 19941220