EP 0736006 A1 19961009 - PHENYLTHIOPHENYL CYCLOALKENYL HYDROXYUREAS AS LIPOXYGENASE INHIBITORS

Title (en)

PHENYLTHIOPHENYL CYCLOALKENYL HYDROXYUREAS AS LIPOXYGENASE INHIBITORS

Title (de)

PHENYLTHIOPHENYL CYCLOALKENYLHYDROXYHARNSTOFFE ALS LIPOXYGENASEHEMMER

Title (fr)

HYDROXYUREES DE CYCLOALCENYLE PHENYLTHIOPHENYLE UTILISEES COMME INHIBITEURS DE LA LYPOXYGENASE

Publication

EP 0736006 A1 19961009 (EN)

Application

EP 95902296 A 19941202

Priority

JP 9402032 W 19941202
JP 34561893 A 19931222

Abstract (en)

[origin: WO9517379A1] Certain novel phenylthiophenylcycloalkenyl hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein A and B, independently, are hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halo-substituted alkyl or C1-C4 halo-substituted alkoxy; R<1> and R<2>, independently, are hydrogen or C1-C3 alkyl; X is S, SO or SO2; and Z is methylene or ethylene. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.

IPC 1-7

C07C 323/47; C07C 317/32; A61K 31/17

IPC 8 full level

A61K 31/17 (2006.01); A61P 3/06 (2006.01); A61P 11/08 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07C 317/32 (2006.01); C07C 323/47 (2006.01)

CPC (source: EP)

A61P 3/06 (2017.12); A61P 11/08 (2017.12); A61P 17/00 (2017.12); A61P 29/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07C 317/32 (2013.01); C07C 323/47 (2013.01); C07C 2601/10 (2017.04)

Citation (search report)

See references of WO 9517379A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9517379 A1 19950629; AU 1120795 A 19950710; CA 2178833 A1 19950629; CO 4230016 A1 19951019; EP 0736006 A1 19961009; FI 946007 A0 19941221; FI 946007 A 19950623; IL 111994 A0 19950315; JP 2756732 B2 19980525; JP H09503226 A 19970331; PE 36395 A1 19951107

DOCDB simple family (application)

JP 9402032 W 19941202; AU 1120795 A 19941202; CA 2178833 A 19941202; CO 94056489 A 19941214; EP 95902296 A 19941202; FI 946007 A 19941221; IL 11199494 A 19941215; JP 51731195 A 19941202; PE 25681894 A 19941212