Title (en)

NOVEL USES FOR GAL4-RECEPTOR CONSTRUCTS

Title (de)

VERWENDUNGEN FÜR GAL 4-REZEPTOR-KONSTRUKTE

Title (fr)

NOUVELLES UTILISATIONS DE PRODUITS DE RECOMBINAISON DE RECEPTEURS DE GAL4

Publication

EP 0737314 A4 19991103 (EN)

Application

EP 95905946 A 19941229

Priority

• US 9414426 W 19941229
• US 17774093 A 19931230

Abstract (en)

[origin: WO9518380A1] In accordance with the present invention, it has been discovered that chimeric receptors comprising at least the ligand binding domain of a member of the steroid/thyroid receptor protein superfamily having incorporated therein the DNA binding domain of the yeast GAL4 protein are capable of forming functional homodimers. Such homodimers are useful, for example, in assays to determine the ligand for an orphan member of the steroid/thyroid superfamily of receptors, for identifying compounds which are selective for a specific steroid/thyroid receptor protein from among a plurality of such receptors which respond to a common ligand, and the like.

IPC 1-7

G01N 33/566; C12P 21/00; C12Q 1/00; C12N 15/00; C12N 1/20

IPC 8 full level

G01N 33/53 (2006.01); C07K 14/395 (2006.01); C07K 14/72 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/00 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01); G01N 33/532 (2006.01); G01N 33/566 (2006.01)

CPC (source: EP)

C07K 14/395 (2013.01); C07K 14/721 (2013.01); G01N 33/5008 (2013.01); G01N 33/502 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

• [Y] WO 9323431 A1 19931125 - BAYLOR COLLEGE MEDICINE [US]
• [Y] WO 9306215 A1 19930401 - SALK INST FOR BIOLOGICAL STUDI [US]
• [Y] WO 9216546 A1 19921001 - SALK INST FOR BIOLOGICAL STUDI [US]
• See references of WO 9518380A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9518380 A1 19950706; AU 1436695 A 19950717; AU 5837496 A 19961003; AU 700646 B2 19990114; CA 2180271 A1 19950706; CA 2182908 A1 19950701; EP 0737314 A1 19961016; EP 0737314 A4 19991103; EP 0743520 A2 19961120; EP 0743520 A3 19991110; JP H09275988 A 19971028; JP H09504111 A 19970422

DOCDB simple family (application)

US 9414426 W 19941229; AU 1436695 A 19941229; AU 5837496 A 19960704; CA 2180271 A 19941229; CA 2182908 A 19941229; EP 95905946 A 19941229; EP 96111192 A 19941229; JP 21728196 A 19960819; JP 51807595 A 19941229