Global Patent Index - EP 0738323 A1

EP 0738323 A1 19961023 - THROMBOPOIETIN

Title (en)

THROMBOPOIETIN

Title (de)

THROMBOPOIETIN

Title (fr)

THROMBOPOIETINE

Publication

EP 0738323 A1 19961023 (EN)

Application

EP 95906653 A 19941228

Priority

  • US 9414553 W 19941228
  • US 17655394 A 19940103
  • US 18560794 A 19940121
  • US 19668994 A 19940215
  • US 22326394 A 19940404
  • US 24937694 A 19940525
  • US 34865794 A 19941202
  • US 34865894 A 19941202

Abstract (en)

[origin: GB2285446A] Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication. differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.

IPC 1-7

C12N 15/19; C07K 14/52; C07K 16/24; A61K 38/19

IPC 8 full level

C12N 15/09 (2006.01); C12N 15/19 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 38/22 (2006.01); A61P 7/00 (2006.01); A61P 7/02 (2006.01); C07H 21/04 (2006.01); C07K 14/52 (2006.01); C07K 16/24 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01); C12N 15/16 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 7/00 (2017.12); A61P 7/02 (2017.12); C07K 14/524 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9518858A1

Citation (third parties)

Third party :

  • US 5830647 A 19981103 - EATON DAN L [US], et al
  • US 5260417 A 19931109 - GRANT BARBARA W [US], et al
  • Detailed Submission
  • F.J.DESAUVAGE: "Stimulation of Megakaryocytopoiesis and Thrombopoiesis by the c-Mpl Ligand", NATURE, vol. 369, 16 June 1994 (1994-06-16), pages 533 - 538, XP000667354
  • HOFFMAN ET AL: "HAEMATOLOGY, BASIC PRINCIPALS AND PRACTICE", vol. 2, part 14, 16 1995, article D.A.WILLIAMS: "Stem Cell Model of Hematopoiesis", pages: 180 - 241, XP000667355
  • MOORE K.L & PERSAUD T.V.N: "THE DEVELOPING HUMAN", vol. 5, 1993, W.B.SAUNDERS COMPANY, ISBN: 0-7216-4662-X, article "Twenty-six to Twenty-nine Weeks", pages: 96, XP000847603
  • CARLSON B.M.: "HUMAN EMBRYOLOGY AND DEVELOPMENTAL BIOLOGY", part 1 1994, MOSBY, ST.LOUIS, ISBN: 0-8016-6415-2, article "Sites of Hematopoiesis", pages: 144, XP000847604
  • HOFFMANN R. ET AL: "HEMATOLOGY - BASIC PRINCIPLES AND PRACTICE", 1991, CHURCHILL LIVINGSTONE, NEW YORK, ISBN: 0-443-08643-5, pages: 258 - 259
  • GOUGH N.M. ET AL: "Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Grnulocyte-Macrophage Colony Stimulating Factor", NATURE, vol. 309, 28 June 1984 (1984-06-28), pages 763 - 767, XP000847673
  • DELAMARTER J.F. ET AL: "Recombinant Murine GM-CSF from E. Coli has Biological Activity and is Neutralized by a Specific Antiserum", THE EMBO JOURNAL, vol. 4, no. 10, 1985, ENGLAND, pages 2575 - 2581, XP000847674
  • FUNG M.C. ET AL: "Molecular Cloning of cDNA for Murine Interleukin-3", NATURE, vol. 307, 1984, pages 233 - 237, XP000847675
  • NAGATA S. ET AL: "Molecular Cloning and Expression of cDNA for Human Granulocyte Colony-Stimulating Factor", NATURE, vol. 319, 30 April 1986 (1986-04-30), pages 415 - 418, XP000847676
  • SULIMAN H.B. ET AL: "Cloning of a cDNA Encoding Bovine Erythropoietin and Analysis of its Transcription in Selected Tissues", GENE, vol. 171, 1996, pages 275 - 280, XP000847677
  • VAN SNICK J. ET AL: "cDNA Cloning of Murine Interleukin-HP1: Homology with Human Interleukin 6", EUR. J. IMMUNOL., vol. 18, 1988, pages 193 - 197, XP000847678
  • WONG G.G. ET AL: "Interleukin 6: Identification as a Hematopoietic Colony-Stimulating Factor", BEHRING INST. MITT., vol. 83, 1988, pages 40 - 47, XP000847679
  • RICHARDS C.D. AND SYKLATVALA J.: "Molecular Cloning and Sequence of Porcine Interleukin 6 cDNA and Expression of mRNA in Synovial Fibroblasts in Vitro", CYTOKINE, vol. 3, no. 4, July 1991 (1991-07-01), pages 269 - 276, XP000847680
  • WITHY R.M.: "Growth Factors Produced by Human Embryonic Kidney Cells that Influence Megakaryopoiesis Include Erythropoietin, Interleukin 6, and Transforming Growth Factor-Beta", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 153, 1992, pages 362 - 372, XP000847681
  • MCDONALD T.P. ET AL: "A Four-Step Procedure for the Purification of Thrombopoietin", INTERNATIONAL SOCIETY FOR EXPERIMENTAL HEMATOLOGY, vol. 17, 1989, USA, pages 865 - 871, XP000847682
  • BARAK Y. ET AL: "Regulation of in Vitro Granulopoiesis by Human Fetal Liver Stromal Cells", PROG. CLIN. BIOL. RES., 1985, pages 157 - 165, XP000847683

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

GB 2285446 A 19950712; GB 2285446 B 19990728; GB 9425831 D0 19950222; AU 1514695 A 19950801; AU 704266 B2 19990415; BG 100693 A 19980130; BG 63639 B1 20020731; CA 2178482 A1 19950713; CA 2178482 C 20120103; CN 1134539 C 20040114; CN 1141061 A 19970122; CZ 192296 A3 19970514; CZ 296130 B6 20060111; DK 149194 A 19950704; EP 0738323 A1 19961023; ES 2114786 A1 19980601; ES 2114786 B1 19990101; FI 121573 B 20110114; FI 962723 A0 19960702; FI 962723 A 19960903; FR 2714670 A1 19950707; FR 2714670 B1 19970110; HR P941020 A2 19970430; HU 9601805 D0 19960828; HU T75657 A 19970528; IE 72517 B1 19970423; IE 950002 A1 19950712; IL 112184 A0 19950315; IL 112184 A 20040725; IT 1283770 B1 19980430; IT TO950002 A0 19950102; IT TO950002 A1 19950703; JP H09508262 A 19970826; JP H10113186 A 19980506; LU 88573 A1 19950601; LV 11632 A 19961220; LV 11632 B 19970420; NL 9500010 A 19950801; NO 326903 B1 20090316; NO 962783 D0 19960702; NO 962783 L 19960903; NZ 278726 A 19980626; PT 101627 A 19951130; PT 101627 B 19961129; RO 117110 B1 20011030; SG 47030 A1 19980320; SI 9420079 A 19970228; SK 282265 B6 20011203; SK 87596 A3 19971105; WO 9518858 A1 19950713

DOCDB simple family (application)

GB 9425831 A 19941221; AU 1514695 A 19941228; BG 10069396 A 19960702; CA 2178482 A 19941228; CN 94194751 A 19941228; CZ 192296 A 19941228; DK 149194 A 19941228; EP 95906653 A 19941228; ES 9402681 A 19941230; FI 962723 A 19960702; FR 9500007 A 19950102; HR P941020 A 19941227; HU 9601805 A 19941228; IE 950002 A 19950103; IL 11218494 A 19941229; IT TO950002 A 19950102; JP 51849995 A 19941228; JP 7490697 A 19970327; LU 88573 A 19950103; LV 960315 A 19960724; NL 9500010 A 19950103; NO 962783 A 19960702; NZ 27872694 A 19941228; PT 10162794 A 19941230; RO 9601347 A 19941228; SG 1996003050 A 19941221; SI 9420079 A 19941228; SK 87596 A 19941228; US 9414553 W 19941228