Global Patent Index - EP 0739204 A4

EP 0739204 A4 2000-03-15 - PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE

Title (en)

PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE

Title (de)

PIPERIDINE, PYRROLIDINE UND HEXAHYDRO-1H-AZEPINE UNTERSTÜTZEN DIE FREISETZUNG DES WACHSTUMSHORMON

Title (fr)

PIPERIDINES, PYRROLIDINES ET HEXAHYDRO-1H-AZEPINES FAVORISANT LA LIBERATION DE L'HORMONE DE CROISSANCE

Publication

EP 0739204 A4 (EN)

Application

EP 95902467 A

Priority

  • US 9412816 W
  • US 14944193 A
  • US 16514993 A
  • US 17344993 A
  • US 32399494 A
  • US 32399894 A
  • US 32398894 A

Abstract (en)

[origin: WO9513069A1] The present invention is directed to certain piperidine, pyrrolidine, and hexahydro-1H-azepine compounds of general structural formula (I) wherein R1, R3, R4, R5, A, W, X, Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

IPC 1-7 (main, further and additional classification)

C07D 401/02; C07D 401/14; C07D 409/02; C07D 453/02; C07K 5/02; C07K 5/06; C07K 5/08

IPC 8 full level (invention and additional information)

C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 453/02 (2006.01); C07K 5/02 (2006.01); C07K 5/06 (2006.01); C07K 5/078 (2006.01); C07K 5/083 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 453/02 (2013.01); C07K 5/0202 (2013.01); C07K 5/021 (2013.01); C07K 5/06034 (2013.01); C07K 5/06139 (2013.01); C07K 5/0808 (2013.01); A61K 38/00 (2013.01); Y02P 20/582 (2015.11)

Citation (search report)

  • [X] EP 0144230 A2 19850612 - PFIZER LTD [GB], et al
  • [A] EP 0513974 A1 19921119 - MERCK & CO INC [US]
  • [X] H.SAKAMOTO ET AL.: "Chymotrypsin Inhibition by Dipeptide Esters, Phenylpepridide and Phenylpeperazides", PEPTIDE CHEMISTRY, vol. 27, 1989, pages 375 - 8, XP002127636
  • See also references of WO 9513069A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9513069 A1 19950518; AU 1172995 A 19950529; BG 100555 A 19961031; BR 9408019 A 19970826; CA 2175218 A1 19950518; CN 1174504 A 19980225; CZ 9601342 A3 19961211; EP 0739204 A1 19961030; EP 0739204 A4 20000315; FI 961951 A0 19960508; FI 961951 A 19960508; HU 9601230 D0 19960729; HU T74733 A 19970228; JP H10506091 A 19980616; LV 11525 A 19961020; LV 11525 B 19970220; NO 961865 A 19960708; NO 961865 D0 19960508; PL 322706 A1 19980216; SK 56296 A3 19970205

INPADOC legal status


2002-12-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020601

2000-03-15 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000128

2000-03-15 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

2000-03-08 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 07D 401/02 A, 7C 07D 401/14 B, 7C 07D 409/02 B, 7C 07K 5/06 B, 7C 07D 453/02 B, 7C 07K 5/02 B, 7C 07K 5/08 B

1996-10-30 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19960610

1996-10-30 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE