Title (en)

4-(2-(3-ARYLOXY-2-HYDROXYPROPYLAMINO ALKYLOXY)-5-NITROPHENYL)-1,4-DIHYDROPYRIDINES AS ANTIHYPERTENSIVE AGENTS

Title (de)

4- (2-(3-ARYLOXY-2-HYDROXYPROPYLAMINOALKYLOXY)-5-NITROPHENYL)-1,4-DIHYDROPYRIDINE MIT ANTIHYPERTENSIVER WIRKUNG

Title (fr)

4-(2-(3-ARYLOXY-2-HYDROXYPROPYLAMINO ALKYLOXY)-5-NITROPHENYL)-1,4-DIHYDROPYRIDINES, UTILISEES COMME AGENTS ANTIHYPERTENSEURS

Publication

EP 0741705 A1 19961113 (EN)

Application

EP 95906531 A 19950127

Priority

• GB 9401730 A 19940129
• GB 9414563 A 19940719
• JP 9500100 W 19950127

Abstract (en)

[origin: WO9520576A1] A dihydropyridine compound of formula (I), wherein: (1) W represents a cyano or halo lower alkyl group; R<1> represents a lower alkyl group; R<2> and R<3>, which may be the same or different, each represents a lower alkyl group; A represents an alkylene group having 1 to 10 carbon atoms; Ar represents an indolyl group, an oxotetrahydronaphthyl group, or a hydroxyl-, cyano-, nitro- or acetyl substituted phenyl group, or (2) W represents a cyano or trifluoromethyl group, R<1>, R<2> and R<3> each represents a methyl group, A represents a tetramethylene group, and Ar represents a 2-tolyl or 2-chlorophenyl group, or (3) W represents a trifluoromethyl group, R<1> and R<3> each represents a methyl group, R<2> represents a methyl or ethyl group, A represents a hexamethylene group, and Ar represents a phenyl group, or (4) W represents a trifluoromethyl group, R<1> and R<2> each represents a methyl group, R<3> represents an isopropyl group, A represents a tetramethylene group, and Ar represents a phenyl group, or an acid addition salt thereof. The invention also provides the individual optical isomers of the compounds of formula (I). The invention further includes processes for the production of the above compounds, pharmaceutical compositions containing same and the use thereof.

IPC 1-7

C07D 211/90; C07D 401/12; A61K 31/445

IPC 8 full level

A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61K 31/451 (2006.01); A61P 9/12 (2006.01); C07D 211/90 (2006.01); C07D 401/12 (2006.01)

CPC (source: EP)

A61P 9/12 (2017.12); C07D 211/90 (2013.01); C07D 401/12 (2013.01)

Citation (search report)

See references of WO 9520576A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9520576 A1 19950803; AU 1467095 A 19950815; EP 0741705 A1 19961113; JP H09510964 A 19971104

DOCDB simple family (application)

JP 9500100 W 19950127; AU 1467095 A 19950127; EP 95906531 A 19950127; JP 51997995 A 19950127