EP 0743944 A1 19961127 - AZACYCLIC DERIVATIVES
Title (en)
AZACYCLIC DERIVATIVES
Title (de)
AZACYCLISCHE DERIVATE
Title (fr)
DERIVES AZACYCLIQUES
Publication
Application
Priority
- EP 9500345 W 19950131
- IT MI940238 A 19940211
Abstract (en)
[origin: WO9521843A1] Azacyclic derivatives of formula (I) in which each of X and Y is independently CH or N; RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring; each of R1 and R2, which may be the same or different, is C1-6 alkyl optionally substituted by at least one of halogen, hydroxy, C1-6 alkoxy, acyloxy, thiol, C1-6 alkylthio, alcylthio, halo-C1-6 alkoxy, CORh, COORh, CONHRh or NCHORh where Rh is hydrogen or C1-6 alkyl; or each of R1 and R2 is hydrogen, C2-6 alkenyl, C3-6 cycloalkyl, or C4-12 cycloalkylalkyl; or R1 and R2 together form an optionally substituted C2-8 branched or linear polymethylene or C2-6 alkenylene group, are kappa-receptor agonists and are useful in the treatment of pain, convulsions, cough, asthma, inflammation, pancreatitits, arrhythmias, hyponatraemic disease states, cerebral ischaemia or skin disorders.
IPC 1-7
IPC 8 full level
A61K 31/495 (2006.01); A61P 1/18 (2006.01); A61P 3/12 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 11/14 (2006.01); A61P 17/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP)
A61P 1/18 (2018.01); A61P 3/12 (2018.01); A61P 9/06 (2018.01); A61P 9/10 (2018.01); A61P 11/00 (2018.01); A61P 11/06 (2018.01); A61P 11/14 (2018.01); A61P 17/00 (2018.01); A61P 25/04 (2018.01); A61P 25/08 (2018.01); A61P 29/00 (2018.01); A61P 43/00 (2018.01); C07D 487/04 (2013.01)
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9521843 A1 19950817; EP 0743944 A1 19961127; IT 1273751 B 19970710; IT MI940238 A0 19940211; IT MI940238 A1 19950811; JP 3135577 B2 20010219; JP H09508635 A 19970902
DOCDB simple family (application)
EP 9500345 W 19950131; EP 95908236 A 19950131; IT MI940238 A 19940211; JP 52093495 A 19950131