EP 0743946 A1 19961127 - 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES
Title (en)
5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES
Title (de)
5HT2B REZEPTOR ANTAGONISTEN KONDENSIERTE INDOLE
Title (fr)
INDOLES CONDENSES A TITRE D'ANTAGONISTES DES RECEPTEURS DE 5HT 2B?
Publication
Application
Priority
- EP 9500427 W 19950206
- GB 9402542 A 19940210
Abstract (en)
[origin: WO9521844A1] Compounds of formula (I) wherein: R<2>, R<3>, R<10> and R<11> are independently hydrogen or alkyl, or R<10> and R<11> together form a bond, or R<2> and R<10> or R<3> and R<11> together form a C<2-6> alkylene chain, and n NOTEQUAL 5 2 or 3. Compounds of formula (I) have 5HTC2C receptor antagonist activity, and certain compounds are potential 5HT2B antagonists. Compounds of the invention are believed to be of potential use in the treatment of CNS disorders such as anxiety, depression, epilepsy, obsessive compulsive disorders, migraine, Alzheimer's disease, sleep disorders, feeding disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia, and also disorders associated with spinal trauma and/or head injury such as hydrocephalus. Compounds of the invention are also expected to be of use in the treatment of certain GI disorders such as IBS as well as microvascular diseases such as macular oedema retinopathy.
IPC 1-7
C07D 487/04; A61K 31/40; C07D 471/04; C07D 487/10; C07D 471/10
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/435 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01); A61P 25/28 (2006.01); A61P 39/02 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01)
CPC (source: EP)
A61P 25/18 (2017.12); A61P 25/20 (2017.12); A61P 25/24 (2017.12); A61P 25/26 (2017.12); A61P 25/28 (2017.12); A61P 39/02 (2017.12); C07D 487/04 (2013.01)
Citation (search report)
See references of WO 9521844A1
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9521844 A1 19950817; EP 0743946 A1 19961127; GB 9402542 D0 19940406; JP H09508637 A 19970902
DOCDB simple family (application)
EP 9500427 W 19950206; EP 95909678 A 19950206; GB 9402542 A 19940210; JP 52095195 A 19950206