Title (en)

PHARMACEUTICAL PIPERAZINE COMPOUNDS

Title (de)

PHARMAZEUTISCHE PIPERAZIN VERBINDUNGEN

Title (fr)

COMPOSES PHARMACEUTIQUES A BASE DE PIPERAZINE

Publication

EP 0745070 A1 19961204 (EN)

Application

EP 95908314 A 19950214

Priority

• GB 9500302 W 19950214
• GB 9402807 A 19940214

Abstract (en)

[origin: GB2286395A] A diketopiperazine of formula (A): <IMAGE> wherein one or both of R1 and R2, which may be the same or different, is: X, substituted phenyl, CH=C(W)V or cyclohexyl; and where appropriate, the other of R1 and R2 is an optionally substituted phenyl group X is a naphthyl group or an optionally substituted five- or six-membered saturated or unsaturated heterocyclic group W is hydrogen or a phenyl group; V is an optionally substituted phenyl group, and the pharmaceutically acceptable salts and esters thereof have activity as inhibitors of plasminogen activator inhibitor.

IPC 1-7

C07D 241/02; C07D 401/06; C07D 405/06; A61K 31/495

IPC 8 full level

C07D 241/18 (2006.01); A61K 31/495 (2006.01); A61K 31/535 (2006.01); A61P 7/02 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); C07D 241/02 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 409/06 (2006.01); C07D 409/14 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01)

CPC (source: EP)

A61P 7/02 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 241/02 (2013.01); C07D 249/08 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/06 (2013.01); C07D 409/06 (2013.01); C07D 409/14 (2013.01)

Citation (search report)

See references of WO 9521832A1

Designated contracting state (EPC)

DE ES FR GB IT NL

DOCDB simple family (publication)

GB 2286395 A 19950816; GB 2286395 B 19980826; GB 9502874 D0 19950405; AU 1667795 A 19950829; AU 693159 B2 19980625; CA 2182877 A1 19950817; EP 0745070 A1 19961204; GB 9402807 D0 19940406; IL 112624 A0 19950526; JP H09509157 A 19970916; WO 9521832 A1 19950817; ZA 951180 B 19960814

DOCDB simple family (application)

GB 9502874 A 19950214; AU 1667795 A 19950214; CA 2182877 A 19950214; EP 95908314 A 19950214; GB 9402807 A 19940214; GB 9500302 W 19950214; IL 11262495 A 19950213; JP 52108295 A 19950214; ZA 951180 A 19950214