EP 0746605 A1 19961211 - MAMMALIAN CATIONIC PROTEINS HAVING LIPOPOLYSACCHARIDE BINDING AND ANTI-COAGULANT ACTIVITY
Title (en)
MAMMALIAN CATIONIC PROTEINS HAVING LIPOPOLYSACCHARIDE BINDING AND ANTI-COAGULANT ACTIVITY
Title (de)
KATIONISCHE SÄUGERPROTEINE WELCHE EINE LIPOPOLYSACCHARID-BINDEAKTIVITÄT UND EINE ANTI-GERINNUNGSAKTIVITÄT HABEN
Title (fr)
PROTEINES CATIONIQUES DE MAMMIFERE A ACTIVITE ANTICOAGULANTE POUVANT SE LIER AUX LIPOPOLYSACCHARIDES
Publication
Application
Priority
- US 9306731 W 19930715
- US 91676192 A 19920717
- US 91676592 A 19920717
Abstract (en)
[origin: WO9402589A1] Compositions and methods for the treatment and diagnosis of lipopolysaccharide-related conditions and coagulant-related disease are provided. Compositions include polypeptides which are identical or homologous to a certain cationic protein (CAP18) obtained from mammalian granulocytes, particularly including a reactive nitrogen inhibiting peptide (RNIP) fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated activation of macrophage, as well as interfering with the clotting cascade to inhibit coagulation in conditions such as disseminated intravascular coagulation. Compositions comprising the polypeptides in a suitable pharmaceutical carrier are also provided.
IPC 1-7
IPC 8 full level
G01N 33/566 (2006.01); A61K 47/48 (2006.01); C07H 21/04 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 14/745 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/4723 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9402589 A1 19940203; AU 4682593 A 19940214; EP 0746605 A1 19961211; EP 0746605 A4 19970416; JP H08504085 A 19960507
DOCDB simple family (application)
US 9306731 W 19930715; AU 4682593 A 19930715; EP 93917249 A 19930715; JP 50460594 A 19930715