EP 0746605 A4 19970416 - MAMMALIAN CATIONIC PROTEINS HAVING LIPOPOLYSACCHARIDE BINDING AND ANTI-COAGULANT ACTIVITY
Title (en)
MAMMALIAN CATIONIC PROTEINS HAVING LIPOPOLYSACCHARIDE BINDING AND ANTI-COAGULANT ACTIVITY
Title (de)
KATIONISCHE SÄUGERPROTEINE WELCHE EINE LIPOPOLYSACCHARID-BINDEAKTIVITÄT UND EINE ANTI-GERINNUNGSAKTIVITÄT HABEN
Title (fr)
PROTEINES CATIONIQUES DE MAMMIFERE A ACTIVITE ANTICOAGULANTE POUVANT SE LIER AUX LIPOPOLYSACCHARIDES
Publication
Application
Priority
- US 9306731 W 19930715
- US 91676192 A 19920717
- US 91676592 A 19920717
Abstract (en)
[origin: WO9402589A1] Compositions and methods for the treatment and diagnosis of lipopolysaccharide-related conditions and coagulant-related disease are provided. Compositions include polypeptides which are identical or homologous to a certain cationic protein (CAP18) obtained from mammalian granulocytes, particularly including a reactive nitrogen inhibiting peptide (RNIP) fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated activation of macrophage, as well as interfering with the clotting cascade to inhibit coagulation in conditions such as disseminated intravascular coagulation. Compositions comprising the polypeptides in a suitable pharmaceutical carrier are also provided.
IPC 1-7
IPC 8 full level
G01N 33/566 (2006.01); A61K 47/48 (2006.01); C07H 21/04 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C07K 14/745 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/4723 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- No further relevant documents disclosed
- See references of WO 9402589A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9402589 A1 19940203; AU 4682593 A 19940214; EP 0746605 A1 19961211; EP 0746605 A4 19970416; JP H08504085 A 19960507
DOCDB simple family (application)
US 9306731 W 19930715; AU 4682593 A 19930715; EP 93917249 A 19930715; JP 50460594 A 19930715