EP 0747062 A2 19961211 - Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same
Title (en)
Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same
Title (de)
Stable Komplexen von vernetzten Polyvinylpyrrolidone und Iod und Verfahren zur Herstellung
Title (fr)
Complexes stables de polyvinylpyrrolidone et de iode, méthode de préparation
Publication
Application
Priority
US 48726095 A 19950607
Abstract (en)
A wound treatment material which absorbs wound fluid without overdrying the wound, provides physical cushioning for the wound, and releases an antimicrobial agent (iodine) in a controlled manner to kill harmful micro-organisms without irritating the wound area or adversely affecting would healing. The wound treatment material comprises crosslinked polyvinylpyrrolidone-iodine complex which is water insoluble, but water-absorbent and water-swellable. When the complex or a wound treatment preparation containing the complex is applied to a wound, i.e., becomes hydrated, and an equilibrium is established between the complex and the wound at the wound/complex interface. Iodine is releaed from the crosslinked polyvinylpyrrolidone-iodine complex by a diffusion controlled process which responds to the reduction in concentration of free iodine in the wound fluid in equilibrium with the complex. The greater the rate of iodine depletion in the wound, the greater the rate of iodine release from the polymer-iodine complex. It has been discovered that this diffusion controlled release mechanism can be utilized to deliver antimicrobially effective amounts of iodine to the wound while maintaining the concentration of iodine below the concentration that could cause significant wound irritation or retardation of healing. It has also been found that the moist environment at the wound/complex interface and the physical protective effect (cushioning) offered by the hydrated complex can enhance wound healing.
IPC 1-7
IPC 8 full level
A61K 47/32 (2006.01); A61K 33/18 (2006.01); A61K 47/48 (2006.01); A61P 17/00 (2006.01); A61P 31/00 (2006.01)
CPC (source: EP US)
A61K 47/58 (2017.07 - EP US); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/02 (2017.12 - EP); A61P 31/04 (2017.12 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 0747062 A2 19961211; EP 0747062 A3 19970806; EP 0747062 B1 20030820; AT E247487 T1 20030915; AU 5464896 A 19961219; AU 722246 B2 20000727; BR 9602671 A 19981006; CA 2178458 A1 19961208; CA 2178458 C 20080122; CN 1089587 C 20020828; CN 1146338 A 19970402; DE 69629519 D1 20030925; DE 69629519 T2 20040624; JP 4416844 B2 20100217; JP H09100235 A 19970415; US 6025446 A 20000215
DOCDB simple family (application)
EP 96304185 A 19960606; AT 96304185 T 19960606; AU 5464896 A 19960531; BR 9602671 A 19960605; CA 2178458 A 19960606; CN 96110781 A 19960607; DE 69629519 T 19960606; JP 16518396 A 19960606; US 2838898 A 19980224