EP 0749422 A1 19961227 - INDOLE DERIVATIVES AS CCK RECEPTOR ANTAGONISTS
Title (en)
INDOLE DERIVATIVES AS CCK RECEPTOR ANTAGONISTS
Title (de)
INDOLDERIVATE ALS CCK REZEPTOR ANTAGONISTEN
Title (fr)
DERIVES D'INDOLE AGISSANT COMME ANTAGONISTES DES RECEPTEURS DE LA CHOLECYSTOKININE
Publication
Application
Priority
US 9402573 W 19940310
Abstract (en)
[origin: WO9524389A1] A novel cholecystokinin antagonist of formula (I) with good bioavailability useful as an agent in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as an antipsychotic is disclosed. Further, the compound is an antianxiety agent and antiulcer agent. It is useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compound of the invention is also useful in treating and/or preventing panic. Also disclosed is a pharmaceutical composition and processes for preparing the compound. An important feature of the instant invention is the absolute oral bioavailability of the compound.
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61P 1/04 (2006.01); A61P 3/04 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/20 (2006.01); A61P 25/30 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 209/18 (2006.01); C07D 209/20 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 209/18 (2013.01 - KR); C07D 209/20 (2013.01 - EP)
Citation (search report)
See references of WO 9524389A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9524389 A1 19950914; AU 6663394 A 19950925; AU 677844 B2 19970508; EP 0749422 A1 19961227; FI 109689 B 20020930; FI 963463 A0 19960904; FI 963463 A 19960904; JP 3361100 B2 20030107; JP H09510440 A 19971021; KR 100311329 B1 20020228; KR 970701694 A 19970412; NO 307176 B1 20000221; NO 963775 D0 19960909; NO 963775 L 19960909; NZ 266052 A 19990729
DOCDB simple family (application)
US 9402573 W 19940310; AU 6663394 A 19940310; EP 94915337 A 19940310; FI 963463 A 19960904; JP 52341095 A 19940310; KR 19960704968 A 19960909; NO 963775 A 19960909; NZ 26605294 A 19940310