EP 0750496 A1 19970102 - USE OF LIPOXYGENASE INHIBITORS AS ANTI-CANCER THERAPEUTIC AND INTERVENTION AGENTS
Title (en)
USE OF LIPOXYGENASE INHIBITORS AS ANTI-CANCER THERAPEUTIC AND INTERVENTION AGENTS
Title (de)
VERWENDUNG VON LIPOXYGENASE-HEMMERN ALS THERAPEUTISCHE UND INTERVENTIONS- ANTIKREBSMITTEL
Title (fr)
UTILISATION D'INHIBITEURS DE LA LIPOXYGENASE EN TANT QU'AGENTS ANTICANCEREUX THERAPEUTIQUES ET D'INTERVENTION
Publication
Application
Priority
- US 9503337 W 19950314
- US 21207494 A 19940314
Abstract (en)
[origin: WO9524894A2] The present method provides a method for treating an epithelial cell-derived cancer in a subject in need of such treatment which comprises administering to the subject an amount of a 5-lipoxygenase inhibitor or derivative thereof effective to treat the epithelial cell-derived cancer. The present invention also provides a method for preventing an epithelial cell-derived cancer in a subject in need of such prevention which comprises administering to the subject an amount of a 5-lipoxygenase inhibitor effective to prevent the epithelial cell-derived cancer. Suitable 5-lipoxygenase inhibitors useful for the methods of the present invention preferably include 2-(12-Hydroxydodeca-5,10-dinyl)-3,5,6-trimethyl-1,4-benzoquinone and derivatives thereof; Nordihydroguaiaretic acid and derivatives; and 3-[1-(4-chlorobenzyl)-3-t-butyl-thio-t-isopropyl-indol-2-yl]-2-2-dimethylpropanoic acid and derivatives thereof. Also intended to be encompassed by this invention are hydroxyurea derivatives as inhibitors of 5-lipoxygenase inhibitors for use in the prevention and treatment of epithelial cell-derived cancers.
IPC 1-7
A61K 31/00; A61K 31/12; A61K 31/05; A61K 31/405; A61K 31/475; A61K 31/38
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/05 (2006.01); A61K 31/12 (2006.01); A61K 31/38 (2006.01); A61K 31/40 (2006.01); A61K 31/405 (2006.01); A61K 31/475 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/05 (2013.01); A61K 31/12 (2013.01); A61K 31/38 (2013.01); A61K 31/40 (2013.01); A61K 31/405 (2013.01); A61K 31/475 (2013.01); A61P 35/00 (2017.12)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9524894 A2 19950921; WO 9524894 A3 19951221; AU 2272295 A 19951003; AU 698313 B2 19981029; CA 2185448 A1 19950921; EP 0750496 A1 19970102
DOCDB simple family (application)
US 9503337 W 19950314; AU 2272295 A 19950314; CA 2185448 A 19950314; EP 95916100 A 19950314