EP 0750511 A4 19990506 - TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR

Title (en)

TREATING INFLAMMATION VIA THE ADMINISTRATION OF SPECIFIC SULFATASE ENZYMES AND/OR SULFATION INHIBITOR

Title (de)

BEHANDLUNG VON ENTZÜNDUNG DURCH DIE GABE VON SPEZIFISCHEN SULFATASE-ENZYMEN UND/ODER INHIBITOREN DER SULFATIERUNG

Title (fr)

TRAITEMENT DES INFLAMMATIONS PAR L'ADMINISTRATION D'ENZYMES SULFATASES SPECIFIQUES ET/OU D'UN INHIBITEUR DE SULFATATION

Publication

EP 0750511 A4 19990506 (EN)

Application

EP 95914060 A 19950315

Priority

US 9503276 W 19950315
US 21494794 A 19940316

Abstract (en)

[origin: WO9524920A1] Compositions are administered to a patient (preferably by injection and locally) to treat a variety of conditions including inflammation associated with trauma and with certain aspects of diseases such as rheumatoid arthritis, psoriasis, insulin-dependent diabetes, cutaneous lymphomas, duodenal ulcer, chronic proctitis, lymphocytic thyroiditis, hemorrhagic shock, reperfusion injury during transplantation and multiple sclerosis. The compositions are pharmaceutically acceptable injectable formulations which include an active component in a pharmaceutically acceptable carrier. The active component is a chlorate or selenate which inhibits the natural biochemical sulfation process and/or a sulfatase enzyme which removes a sulfate from a specific position of a saccharide molecule which makes up a part of a natural ligand for L-selectin. Removal of the sulfate from the ligand hinders the ability of the ligand to bind to its natural receptor (i.e. L-selectin) and thereby hinders a biochemical chain of events which results in inflammation.

IPC 1-7

A61K 38/46; A61K 38/47; A61K 33/04; C12N 9/14; C12N 9/24

IPC 8 full level

A61K 33/04 (2006.01); A61K 38/45 (2006.01); A61K 38/46 (2006.01); A61P 1/00 (2006.01); A61P 3/08 (2006.01); A61P 11/00 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07K 14/705 (2006.01); C12N 9/14 (2006.01); C12N 9/24 (2006.01)

CPC (source: EP)

A61K 33/04 (2013.01); A61K 33/20 (2013.01); A61K 38/465 (2013.01); A61P 1/00 (2017.12); A61P 3/08 (2017.12); A61P 11/00 (2017.12); A61P 17/00 (2017.12); A61P 29/00 (2017.12); A61P 37/00 (2017.12); C07K 14/70596 (2013.01); C12Y 301/06004 (2013.01); C12Y 301/06014 (2013.01)

Citation (search report)

[PX] WO 9406442 A1 19940331 - UNIV CALIFORNIA [US]
[E] WO 9513819 A1 19950526 - UNIV CALIFORNIA [US]
[X] US 4512977 A 19850423 - LUNDY JOSEPH R [US]
[X] E.F.REYNOLDS., ED.: "Martindale - The Extra Pharmacopoeia, 30th Ed.", 1993, THE PHARMACEUTICAL PRESS, LONDON, XP002095171
See references of WO 9524920A1

Designated contracting state (EPC)

DE FR GB

DOCDB simple family (publication)

WO 9524920 A1 19950921; AU 2120995 A 19951003; AU 700369 B2 19990107; CA 2185324 A1 19950921; DE 69531044 D1 20030717; DE 69531044 T2 20031204; EP 0750511 A1 19970102; EP 0750511 A4 19990506; EP 0750511 B1 20030611; JP H10500939 A 19980127

DOCDB simple family (application)

US 9503276 W 19950315; AU 2120995 A 19950315; CA 2185324 A 19950315; DE 69531044 T 19950315; EP 95914060 A 19950315; JP 52417395 A 19950315