EP 0751949 A4 19970820 - ANTI-HEPATITIS B VIRAL OLIGONUCLEOTIDES
Title (en)
ANTI-HEPATITIS B VIRAL OLIGONUCLEOTIDES
Title (de)
VIRALE ANTI-HEPATITIS B OLIGONUKLEOTIDE
Title (fr)
OLIGONUCLEOTIDES ANTI-HBV
Publication
Application
Priority
- US 9413687 W 19941201
- US 17253893 A 19931223
Abstract (en)
[origin: WO9517414A1] The invention relates to methods and compositions for inhibition of viral replication. In particular, complete and irreversible termination of replication of hepatitis B virus is achieved by introducing into a target cell an oligonucleotide complementary to HBV plus strand and 5' and 3' flanking nucleotides.
IPC 1-7
IPC 8 full level
C07H 21/04 (2006.01); A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 31/12 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 31/12 (2017.12); C07H 21/00 (2013.01); C12N 15/1131 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/322 (2013.01)
Citation (search report)
- [AD] W-B. OFFENSPERGER ET AL.: "In vivo inhibition of duck hepatitis B virus replication and gene expression by phophorothioate modified antisense oligodeoxynucleotides.", EMBO J., vol. 12, no. 3, 1993, pages 1257 - 1262, XP000604664
- [AD] D. GANEM ET AL.: "The molecular biology of the hepatitis B viruses", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 56, 1987, pages 651 - 93, XP000672175
- [AD] C. SEEGER ET AL.: "Biochemical and genetic evidence for the Hepatitis B virus replication strategy", SCIENCE, vol. 232, no. 4749, 25 April 1986 (1986-04-25), pages 477 - 484, XP000672129
- See references of WO 9517414A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9517414 A1 19950629; CA 2178811 A1 19950629; EP 0751949 A1 19970108; EP 0751949 A4 19970820; JP H09507062 A 19970715
DOCDB simple family (application)
US 9413687 W 19941201; CA 2178811 A 19941201; EP 95903626 A 19941201; JP 51743395 A 19941201