EP 0752868 A1 19970115 - IMPROVED METHODS FOR TRANSPLANTATION USING MODIFIED CELLS AND T CELL INHIBITORY AGENTS
Title (en)
IMPROVED METHODS FOR TRANSPLANTATION USING MODIFIED CELLS AND T CELL INHIBITORY AGENTS
Title (de)
VERBESSERTE VERFAHREN ZUR TRANSPLANTATION UNTER VERWENDUNG VON MODIFIZIERTEN ZELLEN UND T-ZELLINHIBIERENDEN AGENZIEN
Title (fr)
PROCEDES AMELIORES DE TRANSPLANTATION A L'AIDE DE CELLULES MODIFIEES ET D'AGENTS INHIBITEURS DE LYMPHOCYTES T
Publication
Application
Priority
- US 9503959 W 19950330
- US 22072494 A 19940331
Abstract (en)
[origin: WO9526740A1] Improved methods for inhibiting rejection of transplanted cells in an allogeneic or xenogeneic recipient subject are described. The methods involve altering at least one antigen on the surface of a donor cell prior to transplantation to reduce the immunogenicity of the cell in a recipient subject. Preferably, an MHC class I antigen on a donor cell is altered by contacting the cell with a molecule which binds to the antigen, such as an antibody or fragment or derivative thereof. According to the methods of the invention, a recipient subject is also treated with an agent which inhibits T cell activity in the subject. A preferred agent which inhibits T cell activity in the recipient subject is an immunosuppressive drug, such as cyclosporin A. Alternatively, antibodies which deplete T cells or inhibit T cell proliferation in the subject can be used. Typically, following administration of a modified donor cell to an allogeneic or xenogeneic recipient subject, an immunosuppressive drug is administered to the recipient subject for a sufficient time to induce tolerance to the donor cells.
IPC 1-7
IPC 8 full level
A61K 35/39 (2015.01); A61K 38/13 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
A61K 35/39 (2013.01); A61K 38/13 (2013.01); C07K 16/2833 (2013.01)
Citation (search report)
See references of WO 9526740A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9526740 A1 19951012; AU 2202195 A 19951023; AU 684631 B2 19971218; CA 2186527 A1 19951012; EP 0752868 A1 19970115
DOCDB simple family (application)
US 9503959 W 19950330; AU 2202195 A 19950330; CA 2186527 A 19950330; EP 95914973 A 19950330