EP 0754034 B1 20010711 - EFFERVESCENT PHARMACEUTICAL FORMULATIONS CONTAINING CONTROLLED RELEASE BIODEGRADABLE MICROCAPSULES
Title (en)
EFFERVESCENT PHARMACEUTICAL FORMULATIONS CONTAINING CONTROLLED RELEASE BIODEGRADABLE MICROCAPSULES
Title (de)
PHARMAZEUTISCHE BRAUSEPRÄPARATE ENTHALTEND BIOABBAUBARE MIKROKAPSELN ZUR KONTROLIERTEN WIRKSTOFFFREISETZUNG
Title (fr)
FORMULATIONS PHARMACEUTIQUES EFFERVESCENTES CONTENANT DES MICROGELULES BIODEGRADABLES A LIBERATION CONTROLEE
Publication
Application
Priority
- IE 9500025 W 19950406
- IE 940292 A 19940406
Abstract (en)
[origin: WO9527482A1] Effervescent pharmaceutical formulations for the sustained and controlled oral administration of a drug selected from a calcium channel blocker, an ACE inhibitor, a narcotic analgesic or analogues or combinations thereof, the formulation comprising microcapsules in which the drug is entrapped in a biodegradable polymer, for example poly-L lactide. The pH of the formulation can be varied to optimize the release of the or each drug from the formulation. Microcapsules suitably have a D 50 % between about 100 nm and 900 nm and a drug loading of the order of about 10 % to 70 % by weight. The formulations can be used to administer the drugs to a patient on a once-daily basis so as to achieve a therapeutic effect over a substantially 24-hour period.
IPC 1-7
A61K 9/51; A61K 9/52; A61K 9/46; A61K 9/56; A61K 9/58; A61K 9/64
IPC 8 full level
A61K 9/50 (2006.01); A61K 9/16 (2006.01); A61K 9/46 (2006.01); A61K 9/51 (2006.01); A61K 9/52 (2006.01); A61K 9/56 (2006.01); A61K 9/58 (2006.01); A61K 9/64 (2006.01); B82B 1/00 (2006.01)
CPC (source: EP)
A61K 9/0007 (2013.01); A61K 9/1647 (2013.01); A61K 9/5153 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9527482 A1 19951019; AT E202926 T1 20010715; AU 2223095 A 19951030; DE 69521688 D1 20010816; DE 69521688 T2 20020502; DK 0754034 T3 20010924; EP 0754034 A1 19970122; EP 0754034 B1 20010711; ES 2158101 T3 20010901; GR 3036798 T3 20020131; IE 940292 A1 19951018; JP H09511517 A 19971118; PT 754034 E 20011228
DOCDB simple family (application)
IE 9500025 W 19950406; AT 95915300 T 19950406; AU 2223095 A 19950406; DE 69521688 T 19950406; DK 95915300 T 19950406; EP 95915300 A 19950406; ES 95915300 T 19950406; GR 20010401660 T 20011004; IE 940292 A 19940406; JP 52622195 A 19950406; PT 95915300 T 19950406