Global Patent Index - EP 0755383 A4

EP 0755383 A4 19970827 - INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

FARNESYL-PROTEIN TRANSFERASE INHIBITONEN

Title (fr)

INHIBITEURS DE LA PROTEINE FARNESYL-TRANSFERASE

Publication

EP 0755383 A4 19970827 (EN)

Application

EP 95912860 A 19950310

Priority

  • US 21248994 A 19940314
  • US 9503019 W 19950310

Abstract (en)

[origin: US5439918A] The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.

IPC 1-7

C07D 217/12; A61K 38/00

IPC 8 full level

A61K 31/40 (2006.01); A61K 31/443 (2006.01); A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61K 31/472 (2006.01); A61K 38/55 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 207/16 (2006.01); C07D 211/60 (2006.01); C07D 217/26 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07K 5/078 (2006.01); C07K 5/087 (2006.01); C07K 5/097 (2006.01)

CPC (source: EP US)

A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 207/16 (2013.01 - EP US); C07D 211/60 (2013.01 - EP US); C07D 217/26 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US)

Citation (search report)

  • [A] EP 0523873 A1 19930120 - MERCK & CO INC [US]
  • [A] Y. REISS ET AL.: "Sequence requirement for peptide recognition by rat brain p21(ras) protein farnesyltransferase", PROC. NATL. ACAD. SCI. U.S.A., vol. 88, no. 3, 1991, pages 732 - 736, XP000652098
  • See references of WO 9525092A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

US 5439918 A 19950808; AU 1988495 A 19951003; AU 692241 B2 19980604; CA 2185553 A1 19950921; EP 0755383 A1 19970129; EP 0755383 A4 19970827; JP H09510450 A 19971021; US 6500841 B1 20021231; WO 9525092 A1 19950921

DOCDB simple family (application)

US 21248994 A 19940314; AU 1988495 A 19950310; CA 2185553 A 19950310; EP 95912860 A 19950310; JP 52409795 A 19950310; US 71626096 A 19960912; US 9503019 W 19950310