EP 0755453 A1 19970129 - DNA REGULATORY ELEMENTS RESPONSIVE TO CYTOKINES
Title (en)
DNA REGULATORY ELEMENTS RESPONSIVE TO CYTOKINES
Title (de)
DNA-REGULIERENDE ELEMENTE, DIE AUF ZYTOKINEN REAGIEREN
Title (fr)
ELEMENTS DE REGULATION DE L'ADN SENSIBLES AUX CYTOKINES
Publication
Application
Priority
- US 9504511 W 19950410
- US 22893494 A 19940414
- US 41078095 A 19950327
Abstract (en)
[origin: WO9528492A1] The present invention provides oligonucleotides sequences comprising DNA regulatory elements comprising point mutations of Ly6E GAS element that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonists and antagonists of gene transcription.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/25 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
C12N 15/85 (2013.01); C12Q 1/6811 (2013.01); C12Q 1/6813 (2013.01); C12Q 1/6876 (2013.01); C12Q 1/701 (2013.01); C12Q 2600/156 (2013.01)
Citation (search report)
See references of WO 9528492A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9528492 A1 19951026; AU 2287695 A 19951110; AU 681025 B2 19970814; EP 0755453 A1 19970129; JP H09511908 A 19971202
DOCDB simple family (application)
US 9504511 W 19950410; AU 2287695 A 19950410; EP 95916343 A 19950410; JP 52706795 A 19950410