EP 0757674 A1 19970212 - SUBSTITUTED SULFONAMIDES AS SELECTIVE -g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
Title (en)
SUBSTITUTED SULFONAMIDES AS SELECTIVE -g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
Title (de)
SUBSTITUIERTE SULFONAMIDE ALS SELEKTIVE B3 - AGONISTEN ZUR BEHANDLUNG VON DIABETES UND FETTLEIBIGKEIT
Title (fr)
SULFAMIDES SUBSTITUES UTILISES COMME AGONISTES SELECTIFS VIS-A-VIS DES RECEPTEURS -g(b) 3?-ADRENERGIQUES, POUR LE TRAITEMENT DU DIABETE ET DE L'OBESITE
Publication
Application
Priority
- US 9504956 W 19950421
- US 23316694 A 19940426
- US 40456595 A 19950321
- US 40456695 A 19950321
Abstract (en)
[origin: WO9529159A1] Substituted sulfonamides having formula (I), are selective beta 3 adrenergic receptor agonists with very little beta 1 and beta 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduce neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.
IPC 1-7
C07D 213/30; C07D 413/12; C07D 401/12; C07D 417/14; C07C 311/21; C07D 417/12; C07D 209/08; C07D 233/36; C07D 215/36; A61K 31/44; A61K 31/47
IPC 8 full level
A61K 31/18 (2006.01); A61K 31/275 (2006.01); A61K 31/277 (2006.01); A61K 31/41 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/423 (2006.01); A61K 31/4245 (2006.01); A61K 31/44 (2006.01); A61K 31/4406 (2006.01); A61K 31/4418 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61P 1/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/08 (2006.01); A61P 3/10 (2006.01); A61P 25/02 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01); C07C 311/21 (2006.01); C07C 311/47 (2006.01); C07D 209/08 (2006.01); C07D 213/38 (2006.01); C07D 213/73 (2006.01); C07D 215/36 (2006.01); C07D 233/32 (2006.01); C07D 261/20 (2006.01); C07D 263/32 (2006.01); C07D 271/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/08 (2017.12); A61P 3/10 (2017.12); A61P 25/02 (2017.12); A61P 25/24 (2017.12); A61P 25/26 (2017.12); C07C 311/21 (2013.01); C07C 311/47 (2013.01); C07D 209/08 (2013.01); C07D 213/38 (2013.01); C07D 213/73 (2013.01); C07D 215/36 (2013.01); C07D 233/32 (2013.01); C07D 271/06 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01)
Citation (search report)
See references of WO 9529159A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9529159 A1 19951102; AU 2393795 A 19951116; AU 687558 B2 19980226; CA 2187932 A1 19951102; CN 1149869 A 19970514; CZ 315196 A3 19970813; EP 0757674 A1 19970212; FI 964314 A0 19961025; FI 964314 A 19961025; HU 9602951 D0 19961230; HU T76442 A 19970929; IL 113410 A0 19950731; IL 113410 A 19991130; JP 3149186 B2 20010326; JP H09512275 A 19971209; MX 9605192 A 19970930; NO 964548 D0 19961025; NO 964548 L 19961223; NZ 284718 A 19980226; PL 316969 A1 19970303; SK 136196 A3 19970507
DOCDB simple family (application)
US 9504956 W 19950421; AU 2393795 A 19950421; CA 2187932 A 19950421; CN 95192821 A 19950421; CZ 315196 A 19950421; EP 95917116 A 19950421; FI 964314 A 19961025; HU 9602951 A 19950421; IL 11341095 A 19950418; JP 52779795 A 19950421; MX 9605192 A 19950421; NO 964548 A 19961025; NZ 28471895 A 19950421; PL 31696995 A 19950421; SK 136196 A 19950421