EP 0757676 A1 19970212 - DIHYDRODIBENZO(DE,H)ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS
Title (en)
DIHYDRODIBENZO(DE,H)ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS
Title (de)
DIHYDRO DIBENZO¬DE,H ISOCHINOLIN-DERIVATE UND IHRE VERWENDUNG ALS KREBSMITTEL
Title (fr)
DERIVES DIHYDRODIBENZO(DE,H)ISOQUINOLINES ET LEUR UTILISATION EN TANT QU'AGENTS ANTICANCEREUX
Publication
Application
Priority
- EP 9501347 W 19950412
- US 23399894 A 19940428
Abstract (en)
[origin: WO9529895A1] Novel bis-1,2-dihydro-3H-dibenzisoquinoline-1,3-diones of formula (I), wherein X, X', Y and Y' are identical or different and are each H, NO2, NH2, C1-C6-alkylamino, di-C1-C6 alkylamino, NH-C1-C6-acyl, OH, C1-H6-alkoxy, halogen trihalomethyl, C1-C6-alkyl, formyl, C1-C6-alkylcarbonyl, ureyl, C1-C6-alkylureyl and A is a C4-C12-bridge which is interrupted at one, two or three points by a secondary or tertiary amino group, where two nitrogen atoms may additionally be bonded to one another by a C1-C4-alkylene group or a salt thereof with a physiologically tolerated acid. Processes for their preparation, pharmaceutical compositions containing them and methods of using them to treat malignancies, mainly human solid tumor carcinomas.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61P 35/00 (2006.01); C07D 221/18 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 221/18 (2013.01)
Citation (search report)
See references of WO 9529895A1
Designated contracting state (EPC)
CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9529895 A1 19951109; AU 2306595 A 19951129; CA 2188833 A1 19951109; CN 1092185 C 20021009; CN 1148851 A 19970430; EP 0757676 A1 19970212; HR P950250 A2 19971031; IL 113415 A0 19950731; IL 113415 A 19991130; JP H09512539 A 19971216; SG 73418 A1 20000620; TW 307764 B 19970611; ZA 953379 B 19961028
DOCDB simple family (application)
EP 9501347 W 19950412; AU 2306595 A 19950412; CA 2188833 A 19950412; CN 95193192 A 19950412; EP 95916636 A 19950412; HR P950250 A 19950425; IL 11341595 A 19950418; JP 52795495 A 19950412; SG 1996008471 A 19950412; TW 84103805 A 19950418; ZA 953379 A 19950426