EP 0760675 B1 20010801 - COMPOSITIONS COMPRISING DNA DAMAGING AGENTS AND P53
Title (en)
COMPOSITIONS COMPRISING DNA DAMAGING AGENTS AND P53
Title (de)
ZUSAMMENSETZUNGEN WELCHE DNA ZERSTOERENDE AGENTIEN UND P53 ENTHALTEN
Title (fr)
COMPOSITIONS COMPRENANT DES AGENTS DE DETERIORATION DE L'ADN ET P53
Publication
Application
Priority
- US 9504898 W 19950424
- US 23300294 A 19940425
Abstract (en)
[origin: WO9528948A1] The present invention relates to the use of tumor suppressor genes in combination with a DNA damaging agent or factor for use in killing cells, and in particular cancerous cells. A tumor suppressor gene, p53, was delivered via a recombinant adenovirus-mediated gene transfer both in vitro and in vivo, in combination with a chemotherapeutic agent. Treated cells underwent apoptosis with specific DNA fragmentation. Direct injection of the p53-adenovirus construct into tumors subcutaneously, followed by intraperitoneal administration of a DNA damaging agent, cisplatin, induced massive apoptotic destruction of the tumors. The invention also provides for the clinical application of a regimen combining gene replacement using replication-deficient wild-type p53 adenovirus and DNA-damaging drugs for treatment of human cancer.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 9/08 (2006.01); A61K 31/277 (2006.01); A61K 31/40 (2006.01); A61K 31/407 (2006.01); A61K 31/4745 (2006.01); A61K 31/505 (2006.01); A61K 31/513 (2006.01); A61K 31/70 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 31/711 (2006.01); A61K 33/243 (2019.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61K 51/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12N 15/113 (2010.01); C12N 15/861 (2006.01)
CPC (source: EP KR US)
A61K 31/4745 (2013.01 - EP US); A61K 31/513 (2013.01 - EP US); A61K 31/704 (2013.01 - EP US); A61K 31/7048 (2013.01 - EP US); A61K 31/7072 (2013.01 - EP US); A61K 33/243 (2018.12 - EP US); A61K 38/17 (2013.01 - KR); A61K 45/06 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); C07K 14/4746 (2013.01 - EP US); C07K 14/82 (2013.01 - EP US); C12N 15/1135 (2013.01 - EP US); C12N 15/86 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C12N 2710/10332 (2013.01 - EP US); C12N 2710/10343 (2013.01 - EP US); C12N 2799/022 (2013.01 - EP US)
Citation (examination)
- CANCER RESEARCH 51, 1991, 6304-6311., KARSTAN MB ET AL.
- CANCER RESEARCH 53, 1993, 2212-2216., TISHLER RB ET AL.
- CANCER RESEARCH 53, 1993, 4164-4166., SCHLICHENMEYER WJ ET AL.
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9528948 A1 19951102; AT E203675 T1 20010815; AT E383167 T1 20080115; AU 2392495 A 19951116; AU 694216 B2 19980716; BR 9507506 A 19970902; CA 2188560 A1 19951102; CA 2188560 C 20110719; CN 1147768 A 19970416; CN 1209164 C 20050706; CZ 295144 B6 20050615; CZ 312196 A3 19970813; DE 69521994 D1 20010906; DE 69521994 T2 20020404; DE 69521994 T3 20080626; DE 69535684 D1 20080221; DE 69535684 T2 20090108; EP 0760675 A1 19970312; EP 0760675 B1 20010801; EP 0760675 B2 20071205; EP 1157702 A1 20011128; EP 1157702 B1 20080109; ES 2160707 T3 20011116; ES 2160707 T5 20080516; ES 2298174 T3 20080516; HU 221279 B1 20020928; HU 9602937 D0 19961230; HU T76258 A 19970728; JP 2003277272 A 20031002; JP 3847334 B2 20061122; JP H10503476 A 19980331; KR 100379174 B1 20030802; KR 970702060 A 19970513; NO 20074774 L 19961217; NO 325560 B1 20080616; NO 964527 D0 19961024; NO 964527 L 19961217; NZ 284709 A 19980826; PL 185749 B1 20030731; PL 317105 A1 19970317; RU 2146149 C1 20000310; SK 136796 A3 19970709; SK 283364 B6 20030603; UA 43917 C2 20020115; US 2005089511 A1 20050428; US 2006182718 A1 20060817; US 5747469 A 19980505; US 6069134 A 20000530; US 6797702 B1 20040928; US 7109179 B2 20060919
DOCDB simple family (application)
US 9504898 W 19950424; AT 01110982 T 19950424; AT 95917100 T 19950424; AU 2392495 A 19950424; BR 9507506 A 19950424; CA 2188560 A 19950424; CN 95192776 A 19950424; CZ 312196 A 19950424; DE 69521994 T 19950424; DE 69535684 T 19950424; EP 01110982 A 19950424; EP 95917100 A 19950424; ES 01110982 T 19950424; ES 95917100 T 19950424; HU 9602937 A 19950424; JP 2003028873 A 20030205; JP 52777695 A 19950424; KR 19960705955 A 19961024; NO 20074774 A 20070919; NO 964527 A 19961024; NZ 28470995 A 19950424; PL 31710595 A 19950424; RU 96122787 A 19950424; SK 136796 A 19950424; UA 96103988 A 19950424; US 23300294 A 19940425; US 34850606 A 20060206; US 78453804 A 20040223; US 91840797 A 19970826; US 95329097 A 19971017