Title (en)

VITRONECTIN RECEPTOR ANTAGONISTS

Title (de)

VIBRONECTIN-REZEPTOR-ANTAGONISTEN

Title (fr)

ANTAGONISTES DU RECEPTEUR DE LA VIBRONECTINE

Publication

EP 0762882 A1 19970319 (EN)

Application

EP 95925353 A 19950629

Priority

• US 9508146 W 19950629
• US 26769594 A 19940629

Abstract (en)

[origin: WO9600574A1] Compounds of formula (I) are disclosed which are inhibitors of the vitronectin receptor, wherein X-X' is NR<1>-CH, NC(O)R<3>-CH, N=C, CR<1>=C, CHR<1>-CH, O-CH or S-CH; R<1> is H, C1-6alkyl or benzyl; R<2> is (CH2)nCO2H; R<3> is H, C1-6alkyl, Ar-C0-6alkyl, Het-C0-6 alkyl, or C3-6cycloalkyl-C0-6alkyl; R<4> is W-U, Y-(CHR<5>)m-U or Z-C(O); R<5> and R<6> are independently chosen from H, C1-6alkyl, Ar-C0-6alkyl;, Het-C0-6alkyl and C3-6cycloalkyl-C0-6alkyl; m is 1 or 2; n is 1 or 2; U is NR<1>C(O), C(O)NR<1>, CH=CH, CC, CH2-CH2, O-CH2, CH2-O or CH2OCONR<1>; W is (a), (b) or (c); R<a> is H, OH, NO2, N(R<6>)2, CON(R<6>)2, CH2N(R<6>)2, or R<6>HN-C(=NH); Y is NH2, NHR<6>, N(R<6>)2, C(O)N(R<6>)2, OH, =N-OR<6>, (d), (e) or (f); Z is (g) or (h); R<d> is H, N(R<1>)2, C1-4alkyl, CON(R<1>)2, OH, OR<1>, or Ar-C0-4alkyl; R<e> is H, C1-4alkyl, 2- or 3-pyridinyl, 1-, 2- or 3-piperidinyl, or 2- or 4-pyrimidinyl; and pharmaceutically acceptable salts thereof.

IPC 1-7

A61K 31/55; C07D 243/14

IPC 8 full level

A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61K 31/554 (2006.01); A61P 3/02 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 223/16 (2006.01); C07D 235/14 (2006.01); C07D 243/14 (2006.01); C07D 261/14 (2006.01); C07D 281/10 (2006.01); C07D 295/02 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01)

CPC (source: EP)

A61P 3/02 (2017.12); A61P 19/10 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 223/16 (2013.01); C07D 235/14 (2013.01); C07D 243/14 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 491/04 (2013.01)

Designated contracting state (EPC)

BE CH DE FR GB IT LI NL

DOCDB simple family (publication)

WO 9600574 A1 19960111; EP 0762882 A1 19970319; EP 0762882 A4 20020911; JP H10504807 A 19980512; ZA 955391 B 19960209

DOCDB simple family (application)

US 9508146 W 19950629; EP 95925353 A 19950629; JP 50341896 A 19950629; ZA 955391 A 19950629