EP 0763021 A1 19970319 - PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND TIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS
Title (en)
PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND TIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS
Title (de)
PHENOXYALKYL SUBSTITUIERTE PIPERIDINE, PYROZIDINE, MONPHOZINE UND THIOMONPHOZINE ALS CALCIUM KANAL ANTAGONISTEN
Title (fr)
PIPERIDINES, PYRROLIDINES, MORPHOLINES ET TIOPMORPHOLINES A SUBSTITUTION PHENOXYALCOYLE EN TANT QU'ANTAGONISTES DES CANAUX CALCIQUES
Publication
Application
Priority
- EP 9502002 W 19950524
- GB 9411052 A 19940602
Abstract (en)
[origin: WO9533722A1] Compounds of formula (I) in which W is -(CH2)4, (CH2)5, -(CH2)2O(CH2)2 or -(CH2)2S(CH2)2, n is 0 to 6; m is 0 to 3; A is a bond, -CH=CH-, -CC-, oxygen, sulphur or NR<1>; R<1> is hydrogen, C1-8alkyl or phenylC1-4alkyl; and Ar is a group (a) where X is -SO2- or -C(CH3)2-, Y and Z may each be hydrogen, fluorine, chlorine, bromine, C1-4alkyl, C1-4alkoxy or trifluoromethyl; and salts thereof are calcium channel antagonists with activity in neurons and are useful in the treatment of conditions such as ischaemic stroke.
IPC 1-7
IPC 8 full level
A61K 31/42 (2006.01); A61K 31/445 (2006.01); A61K 31/535 (2006.01); A61K 31/5375 (2006.01); A61P 3/00 (2006.01); A61P 3/14 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); C07D 211/22 (2006.01); C07D 211/24 (2006.01); C07D 211/32 (2006.01); C07D 265/30 (2006.01); C07D 279/12 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/14 (2017.12); A61P 9/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/08 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); C07D 211/22 (2013.01); C07D 211/24 (2013.01)
Citation (search report)
See references of WO 9533722A1
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL
DOCDB simple family (publication)
WO 9533722 A1 19951214; EP 0763021 A1 19970319; GB 9411052 D0 19940720; JP H10500967 A 19980127
DOCDB simple family (application)
EP 9502002 W 19950524; EP 95921758 A 19950524; GB 9411052 A 19940602; JP 50028995 A 19950524