EP 0764154 A1 19970326 - NEW TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (en)
NEW TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (de)
TAXAL DERIVATE, DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSTELLUNGEN
Title (fr)
NOUVEAUX TAXOIDES, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Publication
Application
Priority
- FR 9500735 W 19950607
- FR 9407049 A 19940609
Abstract (en)
[origin: WO9533736A1] New taxoids having general formula (I), (II) preparation thereof and pharmaceutical compositions containing them. In general formula (I): Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy, and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function, Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, a thenyl or furoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, similar or different, represent an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, aryl or heterocyclyl radical, with the condition that R5 does not represent a methyl radical. The new products having general formula (I) wherein Z is a radical having general formula (II) have remarkable antitumoral and antileukaemic properties.
IPC 1-7
IPC 8 full level
A61K 31/335 (2006.01); A61K 31/337 (2006.01); A61P 35/00 (2006.01); C07D 305/14 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 305/14 (2013.01)
Citation (search report)
See references of WO 9533736A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9533736 A1 19951214; AU 2741795 A 19960104; AU 692269 B2 19980604; CA 2190651 A1 19951214; CN 1150423 A 19970521; CZ 358396 A3 19970312; EP 0764154 A1 19970326; FI 964900 A0 19961205; FI 964900 A 19961205; FR 2721023 A1 19951215; FR 2721023 B1 19960712; HU 9603388 D0 19970128; HU T77224 A 19980302; JP H10500979 A 19980127; PL 317467 A1 19970414; SK 158096 A3 19970709; TW 318845 B 19971101; ZA 954655 B 19960213
DOCDB simple family (application)
FR 9500735 W 19950607; AU 2741795 A 19950607; CA 2190651 A 19950607; CN 95193482 A 19950607; CZ 358396 A 19950607; EP 95922569 A 19950607; FI 964900 A 19961205; FR 9407049 A 19940609; HU 9603388 A 19950607; JP 50045996 A 19950607; PL 31746795 A 19950607; SK 158096 A 19950607; TW 84105738 A 19950607; ZA 954655 A 19950606