EP 0764156 A1 19970326 - NEW TAXOIDS, PREPARATION THEREOF AND PHAMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (en)
NEW TAXOIDS, PREPARATION THEREOF AND PHAMACEUTICAL COMPOSITIONS CONTAINING THEM
Title (de)
TAXOL DERIVATE, DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSTELLUNGEN
Title (fr)
NOUVEAUX TAXOIDES, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Publication
Application
Priority
- FR 9500738 W 19950607
- FR 9407052 A 19940609
Abstract (en)
[origin: WO9533739A1] New taxoids having general formula (I), (II), preparation thereof and pharmaceutical compositions containing them. In general formula (I), Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function; Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, thenoyl or furoyl or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, which are the same or different, represent an alkyl, alkenyl, alkynyl, cycoalkyl, cycloalkenyl, bicycloalkyl, aryl, or heterocyclyl radical, R5 not representing a methyl radical. The new products having general formula (I) wherein Z is a radical of general formula (II) have remarkable antitumoral and antileukaemic properties.
IPC 1-7
IPC 8 full level
A61K 31/335 (2006.01); A61K 31/337 (2006.01); A61P 35/00 (2006.01); C07D 305/14 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 305/14 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01)
Citation (search report)
See references of WO 9533739A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9533739 A1 19951214; AU 2742095 A 19960104; CA 2190657 A1 19951214; EP 0764156 A1 19970326; FR 2721026 A1 19951215; FR 2721026 B1 19960712; JP H10500981 A 19980127
DOCDB simple family (application)
FR 9500738 W 19950607; AU 2742095 A 19950607; CA 2190657 A 19950607; EP 95922572 A 19950607; FR 9407052 A 19940609; JP 50046296 A 19950607