EP 0764207 A1 19970326 - MODIFIED CELLS AND METHODS FOR INHIBITING HYPERACUTE REJECTION OF XENOGENEIC TRANSPLANTS
Title (en)
MODIFIED CELLS AND METHODS FOR INHIBITING HYPERACUTE REJECTION OF XENOGENEIC TRANSPLANTS
Title (de)
MODIFIZIERTE ZELLEN UND VERFAHREN ZUR INHIBIERUNG DER HYPERAKUTEN ABSTOSSUNG VON XENOGENE TRANPLANTATEN
Title (fr)
MODIFICATION CELLULAIRE ET PROCEDES D'INHIBITION DES REACTIONS SURAIGUES DE REJET DES XENOGREFFES
Publication
Application
Priority
- US 9505973 W 19950517
- US 25378294 A 19940603
Abstract (en)
[origin: WO9533828A1] Modified cells for transplantation having reduced capacity to stimulate natural antibody-mediated hyperacute rejection of the cell in a transplant recipient are disclosed. In unmodified form, cells for use in xenogeneic transplantation express at least one epitope on a cell surface antigen which is bound by natural antibodies in a recipient. Prior to transplantation, the cells are modified to alter, reduce or substantially eliminate expression of the epitope on the cell surface. Preferably, the cell is a porcine cell and the epitope is a galactosyl ( alpha 1,3) galactose epitope. Methods for reducing the immunogenicity of a cell for transplantation into a recipient are also disclosed. Modified cells of the invention can additionally be treated to alter, reduce or substantially eliminate another surface antigen (e.g., an MHC class I antigen) which stimulates a cellular immune response against the cell in a recipient. Additionally, a recipient can be treated with an agent which inhibits T cell activity, such as an immunosuppressive drug or an anti-T cell antibody.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); C12N 9/40 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61K 39/001 (2013.01 - EP); C12N 9/2465 (2013.01 - EP); C12N 15/1137 (2013.01 - EP); C12Y 204/01228 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 2039/5156 (2013.01 - EP US); C12N 2510/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9533828 A1 19951214; AU 2587995 A 19960104; AU 708880 B2 19990812; CA 2191891 A1 19951214; EP 0764207 A1 19970326
DOCDB simple family (application)
US 9505973 W 19950517; AU 2587995 A 19950517; CA 2191891 A 19950517; EP 95920424 A 19950517