Global Patent Index - EP 0764272 B1

EP 0764272 B1 20010103 - PTPalpha detection in tumour diagnosis and prognosis

Title (en)

PTPalpha detection in tumour diagnosis and prognosis

Title (de)

PTPalpha-Bestimmung in der Tumordiagnose und -Prognose

Title (fr)

Détection de PTPalpha dans le diagnostic et pronostic de tumeurs

Publication

EP 0764272 B1 20010103 (EN)

Application

EP 95922516 A 19950606

Priority

  • EP 9502166 W 19950606
  • GB 9411671 A 19940610

Abstract (en)

[origin: WO9534818A1] It has been found that the level of protein tyrosine phosphatase alpha (PTP alpha ) expression is increased in significant numbers of tumors and that PTP alpha can be used as a marker for the diagnosis or prognosis of cancers. Accordingly, the invention provides a method for diagnosis or prognosis of a cancer, which method comprises detection of PTP alpha or PTP alpha nucleic acid. In general, the level of PTP alpha or PTP alpha nucleic acid in a first biological sample derived from tissue suspected of being neoplastic or potentially neoplastic is compared with the level in a second biological sample derived from normal tissue.

[origin: WO9534818A1] It has been found that the level of protein tyrosine phosphatase alpha (PTP alpha ) expression is increased in significant numbers of tumors and that PTP alpha can be used as a marker for the diagnosis or prognosis of cancers. Accordingly, the invention provides a method for diagnosis or prognosis of a cancer, which method comprises detection of PTP alpha or PTP alpha nucleic acid. In general, the level of PTP alpha or PTP alpha nucleic acid in a first biological sample derived from tissue suspected of being neoplastic or potentially neoplastic is compared with the level in a second biological sample derived from normal tissue.

IPC 1-7

G01N 33/574; G01N 33/573; C12Q 1/68

IPC 8 full level

G01N 33/574 (2006.01)

CPC (source: EP US)

G01N 33/57446 (2013.01 - EP US); G01N 2474/20 (2021.08 - EP US)

Citation (examination)

SCHUH ET AL.: "Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice", NATURE, vol. 346, 23 August 1990 (1990-08-23), pages 756 - 760

Designated contracting state (EPC)

AT CH DE FR GB IT LI

DOCDB simple family (publication)

WO 9534818 A1 19951221; AT E198513 T1 20010115; AU 2738195 A 19960105; DE 69519796 D1 20010208; DE 69519796 T2 20010419; EP 0764272 A1 19970326; EP 0764272 B1 20010103; GB 9411671 D0 19940803; US 5888746 A 19990330

DOCDB simple family (application)

EP 9502166 W 19950606; AT 95922516 T 19950606; AU 2738195 A 19950606; DE 69519796 T 19950606; EP 95922516 A 19950606; GB 9411671 A 19940610; US 75035297 A 19970310