EP 0767671 A1 19970416 - METHOD OF COMBATING ACYCLOVIR-RESISTANT HERPES SIMPLEX VIRAL INFECTIONS
Title (en)
METHOD OF COMBATING ACYCLOVIR-RESISTANT HERPES SIMPLEX VIRAL INFECTIONS
Title (de)
METHODE ZU BEKÄMPFEN ACYCLOVIR-RESISTENTER VIRALER HERPES-SIMPLEX-INFEKTIONEN
Title (fr)
PROCEDE PERMETTANT DE LUTTER CONTRE DES INFECTIONS VIRALES DUES A L'HERPES SIMPLEX ET RESISTANTES A L'ACYCLOVIR
Publication
Application
Priority
- CA 9400242 W 19940429
- CA 2095408 A 19930503
Abstract (en)
[origin: WO9425046A1] Disclosed herein is a method for treating acyclovir-resistant herpes infections in a mammal. The method comprises administering a peptide derivative or a combination of the peptide derivative and an antiviral nucleoside analog to the infected mammal. The peptide derivative used for the method is represented by the formula A-B-D-CH2CH{CH2C(O)R<1>}C(O)-NHCH{CR<2>(R<3>)COOH}C(O)-E wherein A is a terminal group, for example an optionally substituted phenylalkanoyl, and B is an N-methyl amino acid residue; or A and B together form a saturated alkylaminocarbonyl; D is an amino acid residue; R<1> is, for example, an alkyl, cycloalkyl, or a monosubstituted or a disubstituted amino; R<2> is, for example, hydrogen or alkyl and R<3> is alkyl, or R<2> is hydrogen and R<3> is phenylalkyl, or R<2> and R<3> are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 31/195 (2006.01); A61K 31/52 (2006.01); A61K 38/04 (2006.01); A61P 31/12 (2006.01); A61P 31/22 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP KR)
A61K 31/195 (2013.01 - EP); A61K 31/52 (2013.01 - EP); A61K 31/70 (2013.01 - EP); A61K 38/00 (2013.01 - KR); A61K 38/04 (2013.01 - EP); A61P 31/12 (2017.12 - EP); A61P 31/22 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (search report)
See references of WO 9425046A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9425046 A1 19941110; AU 6642394 A 19941121; AU 683465 B2 19971113; BR 9406575 A 19960319; CA 2095408 A1 19941104; CN 1126438 A 19960710; CZ 287795 A3 19960612; EP 0767671 A1 19970416; HU 9503135 D0 19960129; HU T73779 A 19960930; JP H08509476 A 19961008; KR 960701651 A 19960328; NO 954390 D0 19951102; NO 954390 L 19960102; SG 48806 A1 19980518; SK 132695 A3 19961002
DOCDB simple family (application)
CA 9400242 W 19940429; AU 6642394 A 19940429; BR 9406575 A 19940429; CA 2095408 A 19930503; CN 94192662 A 19940429; CZ 287795 A 19940429; EP 94914991 A 19940429; HU 9503135 A 19940429; JP 52370594 A 19940429; KR 19950704828 A 19951102; NO 954390 A 19951102; SG 1996001910 A 19940429; SK 132695 A 19940429