EP 0769055 A1 19970423 - VARIANTS OF LEUKEMIA INHIBITORY FACTOR
Title (en)
VARIANTS OF LEUKEMIA INHIBITORY FACTOR
Title (de)
VARIANTEN VON LEUKAEMIE-HEMMENDEN-FAKTOR
Title (fr)
VARIANTES DU FACTEUR INHIBITEUR DE LA LEUCEMIE
Publication
Application
Priority
- GB 9501528 W 19950630
- GB 9413316 A 19940701
Abstract (en)
[origin: WO9601319A1] The invention provides proteins which are variants of human Leukemia Inhibitory Factor (hLIF) with altered binding affinities to the LIF receptor and to the gp130 receptor. Such proteins include hLIF which has been altered by substitution at, insertion into, or deletion within a portion of said sequence such that the affinity for the LIF receptor is lowered compared to LIF, or a fragment of said protein which contains said alteration. Such proteins also include hLIF which has been altered by substitution at, insertion into, or deletion within a portion of said sequence such that the affinity for the gp130 receptor is lowered compared to LIF, or a fragment of said protein which contains said alteration.
IPC 1-7
C12N 15/24; C12N 1/21; C07K 16/24; A61K 38/20; C07K 14/54; C07K 14/475; C07K 14/52
IPC 8 full level
C07K 14/475 (2006.01); C07K 14/52 (2006.01); C07K 14/54 (2006.01); C12N 15/24 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/475 (2013.01); C07K 14/52 (2013.01); C07K 14/54 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9601319A1
Designated contracting state (EPC)
CH DE DK FR GB IT LI NL
DOCDB simple family (publication)
WO 9601319 A1 19960118; AU 2800795 A 19960125; EP 0769055 A1 19970423; GB 9413316 D0 19940824
DOCDB simple family (application)
GB 9501528 W 19950630; AU 2800795 A 19950630; EP 95923449 A 19950630; GB 9413316 A 19940701