EP 0771323 A1 19970507 - CORTICOTROPIN-RELEASING FACTOR-BINDING-PROTEIN INHIBITORS AND THEIR USE
Title (en)
CORTICOTROPIN-RELEASING FACTOR-BINDING-PROTEIN INHIBITORS AND THEIR USE
Title (de)
CRF-BP INHIBITOREN UND DEREN VERWENDUNG
Title (fr)
INHIBITEURS DE LA PROTEINE DE LIAISON DU FACTEUR DE LIBERATION DE LA CORTICOTROPINE
Publication
Application
Priority
- US 27624094 A 19940715
- US 48477695 A 19950607
- US 9508867 W 19950714
Abstract (en)
[origin: CA2195197A1] Levels of free corticotropin-releasing factor (CRF) in the brain are increased by administration to a patient of a ligand inhibitor of a CRF/CRF-binding protein complex. The ligand inhibitor binds to CRF-binding protein causing the release of CRF. The ligand inhibitor may be a peptide derived from CRF or a related protein or a non-peptide. Administration of the ligand inhibitor may provide improvement in learning and memory, resulting in decreased food intake or provide treatment for diseases associated with low levels of CRF in the brain, notably Alzheimer's disease. A method is also provided for screening compounds to select particularly effective CRF antagonists for in vivo administration to mammals.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/03 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61P 15/04 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); C07K 4/12 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); G01N 33/53 (2006.01); G01N 33/541 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)
IPC 8 main group level
C07K (2006.01)
CPC (source: EP)
C07K 14/57509 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9602569A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 3128395 A 19960216; AU 705984 B2 19990603; CA 2195197 A1 19960201; CN 1157620 A 19970820; EP 0771323 A1 19970507; JP 2001348400 A 20011218; JP H10503187 A 19980324; MX 9700413 A 19980531; NO 970165 D0 19970114; NO 970165 L 19970314
DOCDB simple family (application)
AU 3128395 A 19950714; CA 2195197 A 19950714; CN 95194716 A 19950714; EP 95927176 A 19950714; JP 2001120416 A 20010418; JP 50517796 A 19950714; MX 9700413 A 19950714; NO 970165 A 19970114