Global Patent Index - EP 0773958 A1

EP 0773958 A1 19970521 - PTH OR PTHrP ANTAGONISTS

Title (en)

PTH OR PTHrP ANTAGONISTS

Title (de)

PTH ODER PTHrP ANTAGONISTEN

Title (fr)

ANTAGONISTES DE LA PTH OU DU PTH-rP

Publication

EP 0773958 A1 19970521 (EN)

Application

EP 95927739 A 19950727

Priority

  • EP 9502993 W 19950727
  • GB 9415254 A 19940728
  • GB 9415255 A 19940728

Abstract (en)

[origin: WO9603437A1] PTH or PTHrP compounds having potent antagonistic activity at the PTH/PTHrP receptor in which at least one of the amino acid residues naturally occurring in positions 2 and 10 is replaced by tryptophane or another amino acid residue bearing an aromatic or heteroaromatic group on its side chain, and optionally at least one of the amino acid residues naturally occurring in positions 3 and 6 is further replaced by tryptophane or another amino acid residue bearing an aromatic or heteroaromatic group on its side chain, having pharmacological activity, e.g. prevention or treatment of conditions which are associated with increased plasma calcium caused by excessive release of PTH or PTHrP.

IPC 1-7

C07K 14/635; A61K 38/29

IPC 8 full level

A61K 8/00 (2006.01); A61K 8/64 (2006.01); A61K 38/26 (2006.01); A61P 17/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); A61Q 5/00 (2006.01); A61Q 7/00 (2006.01); A61Q 19/00 (2006.01); C07K 14/635 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 17/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/635 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9603437A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9603437 A1 19960208; AU 3167095 A 19960222; BR 9508433 A 19980714; CA 2192787 A1 19960208; CO 4410206 A1 19970109; CZ 23397 A3 19970716; EP 0773958 A1 19970521; FI 970168 A0 19970115; FI 970168 A 19970115; HU T77979 A 19990128; IL 114736 A0 19951127; JP H10502091 A 19980224; MX 9700446 A 19980628; NO 970356 D0 19970128; NO 970356 L 19970128; PL 318017 A1 19970512; SK 12097 A3 19970806; TR 199500915 A2 19960621

DOCDB simple family (application)

EP 9502993 W 19950727; AU 3167095 A 19950727; BR 9508433 A 19950727; CA 2192787 A 19950727; CO 95032396 A 19950721; CZ 23397 A 19950727; EP 95927739 A 19950727; FI 970168 A 19970115; HU 9700245 A 19950727; IL 11473695 A 19950726; JP 50548996 A 19950727; MX 9700446 A 19970116; NO 970356 A 19970128; PL 31801795 A 19950727; SK 12097 A 19950727; TR 9500915 A 19950728