EP 0774000 A1 19970521 - ANTIBODIES THAT BIND A CONFORMATIONALLY ALTERED CD4 MOLECULE INDUCED UPON HUMAN IMMUNODEFFICIENCY VIRUS BINDING
Title (en)
ANTIBODIES THAT BIND A CONFORMATIONALLY ALTERED CD4 MOLECULE INDUCED UPON HUMAN IMMUNODEFFICIENCY VIRUS BINDING
Title (de)
ANTIKORPER DIE EIN KONFORMATIONSGEANDERTES CD4 MOLEKUL BINDEN, HERVORGERUFEN DURCH DIE BINDUNG DES MENSCHLICHEN IMMUNSCHWACHEVIRUS
Title (fr)
ANTICORPS SE FIXANT A UNE MOLECULE CD4 A CONFORMATION MODIFIEE, INDUITE PAR FIXATION DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE
Publication
Application
Priority
- US 9509114 W 19950719
- US 27708094 A 19940719
- US 30590394 A 19940913
Abstract (en)
[origin: WO9602647A1] Antibodies that bind a conformationally altered form of CD4 induced on the surface of a CD4<+> cell upon contact of the cell with human immunodeficiency virus (HIV), or an envelope protein thereof (e.g., gp120), but which do not substantially bind native CD4 on the surface of a cell prior to contact with HIV or an envelope protein thereof, are disclosed. Preferred antibodies of the invention are the monoclonal Fab fragments 3-47 and 3-51. Pharmaceutical compositions, and diagnostic, screening and therapeutic methods utilizing the antibodies of the invention are also disclosed. The antibodies of the invention are useful for detecting a conformationally altered form of CD4 on the surface of a cell, for identifying agents that inhibit or induce formation of this conformationally altered form of CD4 upon gp120 binding, and for inhibiting infection of CD4<+> cells by HIV. Molecules that express at least one epitope expressed on a conformationally altered form of CD4 induced on the surface of a CD4<+> cell upon contact of the cell with HIV, or an envelope protein thereof, are also encompassed by the invention. Such molecules can be used to produce antibodies of the invention and to induce an antibody response in a subject that inhibits infection of cells in the subject by HIV.
IPC 1-7
C12N 15/13; C07K 16/28; A61K 39/395; C12N 15/85; C12N 5/20; G01N 33/569; G01N 33/577; C07K 14/73; A61K 38/17; A61K 39/00
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); C07K 14/73 (2006.01); C07K 16/28 (2006.01); C12N 1/21 (2006.01); C12N 15/02 (2006.01); C12N 15/13 (2006.01); C12P 21/08 (2006.01); A61K 39/00 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP US)
C07K 14/70514 (2013.01 - EP); C07K 16/2812 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 39/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9602647 A1 19960201; AU 3196895 A 19960216; CA 2195238 A1 19960201; EP 0774000 A1 19970521; JP H10505490 A 19980602
DOCDB simple family (application)
US 9509114 W 19950719; AU 3196895 A 19950719; CA 2195238 A 19950719; EP 95928088 A 19950719; JP 50525196 A 19950719