EP 0775697 B1 20030212 - Process for producing 1-substituted tetrahydroquinazolindionen
Title (en)
Process for producing 1-substituted tetrahydroquinazolindionen
Title (de)
Verfahren zur Herstellung von 1-substituierten Tetrahydrochinazolindionen
Title (fr)
Procédé pour la préparation de tétrahydroquinazolindiones 1-substitués
Publication
Application
Priority
JP 29543595 A 19951114
Abstract (en)
[origin: EP0775697A1] A process for producing a 1-substituted tetrahydroquinazoline represented by the formula (III): <CHEM> wherein Z represents a methylene group which is optionally substituted by an alkyl group; R6 represents an alkyl group or an aralkyl group; R1 and R2 independently represent a hydrogen atom, a halogen atom, a nitro group, an azido group, an alkyl group, an alkenyl group, an aralkyl group, an alkoxy qroupm, an alkoxycarbonyl group, an acyloxy group, or an amino group represented by XNR4R5in which X represents a direct bond, an alkylene group or a carbonyl group, and N, R4 and R5 may form together a five- or six-membered heterocyclic ring or R4 and R5 independently represent an alkyl group or an acyloxy alkyl group; and R3 represents a hydrogen atom, a halogen atom, a nitro group, an azido group, an alkyl group, an alkenyl group, an aralkyl qroup, an alkoxy group, or an alkoxycarbonyl group which comprises reacting tetrahydroquinazolines represented by the formula (I): <CHEM> wherein R1, R2 and R3 are as defined above with hexamethyldisilazane; and reacting the resultant product with a chloroalkanoate represented by the formula (II): C1-Z-CO-O-R6 wherein Z and R6 are as defined above in the presence of an iodide of an alkaline metal, followed by desilylation.
IPC 1-7
IPC 8 full level
C07D 239/96 (2006.01)
CPC (source: EP US)
C07D 239/96 (2013.01 - EP US)
Citation (examination)
EP 0878468 A1 19981118 - SUMITOMO CHEMICAL CO [JP]
Designated contracting state (EPC)
DE FR GB IT SE
DOCDB simple family (publication)
EP 0775697 A1 19970528; EP 0775697 B1 20030212; CA 2190236 A1 19970515; CA 2190236 C 20000125; DE 69626171 D1 20030320; DE 69626171 T2 20031023; US 5756738 A 19980526
DOCDB simple family (application)
EP 96308239 A 19961114; CA 2190236 A 19961113; DE 69626171 T 19961114; US 74782296 A 19961113