EP 0777736 A1 19970611 - FUNCTIONAL MODIFIED HSV1-TK

Title (en)

FUNCTIONAL MODIFIED HSV1-TK

Title (de)

FUNKTIONELLE MODIFIZIERTE HSV1-TK

Title (fr)

HSV1-TK MODIFIEE FONCTIONNELLE

Publication

EP 0777736 A1 19970611 (FR)

Application

EP 95927796 A 19950817

Priority

FR 9501098 W 19950817
FR 9410298 A 19940825

Abstract (en)

[origin: WO9606176A1] Recombinant vector carrying a gene coding for a promotor-dependent kinase and capable, when expressed in the cells transformed by the vector, of bringing out the phosphorylation of nucleoside analogues such as aciclovir or ganciclovir leading to the death of the cell by blocking the replication process. The recombinant vector is characterized in that the kinase-coding gene is the thymidine kinase gene of type 1 herpes simplex virus (HSV1-TK) deleted in the 5' portion of all or part of the sequence upstream from the second ATG initiation codon corresponding to the methionine 46 of the complete protein.

IPC 1-7

C12N 15/57; C12N 15/86; C12N 5/10; C12N 9/12; C07K 14/035; A61K 48/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/52 (2006.01); A61K 35/76 (2006.01); A61K 38/45 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 37/06 (2006.01); C07K 14/035 (2006.01); C12N 5/00 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/57 (2006.01); C12N 15/867 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP US)

A61K 38/45 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); C12N 9/12 (2013.01 - EP US); C12N 15/86 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); C12N 2710/16622 (2013.01 - EP US); C12N 2740/16043 (2013.01 - EP US)

Citation (search report)

See references of WO 9606176A1

Designated contracting state (EPC)

DE ES FR GB IT

DOCDB simple family (publication)

WO 9606176 A1 19960229; EP 0777736 A1 19970611; FR 2723962 A1 19960301; FR 2723962 B1 19961031; JP H10506007 A 19980616; US 6004803 A 19991221

DOCDB simple family (application)

FR 9501098 W 19950817; EP 95927796 A 19950817; FR 9410298 A 19940825; JP 50782495 A 19950817; US 79351897 A 19970411