Title (en)

OLIGONUCLEOTIDE CONJUGATES, COMPOSITIONS AND METHODS FOR SPLITTING RIBONUCLEIC ACIDS

Title (de)

OLIGONUKLEOTIDKONJUGATE, ZUSAMMENSETZUNGEN UND VERFAHREN ZUR SPALTUNG VON RIBONUKLEINSÄUREN

Title (fr)

CONJUGUES D'OLIGONUCLEOTIDES, COMPOSITIONS ET PROCEDES DE DIVISION D'ACIDES RIBONUCLEIQUES

Publication

EP 0778845 A1 19970618 (DE)

Application

EP 95931942 A 19950830

Priority

• CH 269494 A 19940902
• EP 9503408 W 19950830

Abstract (en)

[origin: WO9607667A1] The invention pertains to an oligonucleotide characterized in that a transesterification or hydrolysis catalyst is bonded to the oligonucleotide, the inner sequence of the oligonucleotide is partially noncomplementary to a naturally occurring target RNA, and the oligonucleotide is composed of deoxyribonucleic acid units, unnatural synthetic nucleotide units or peptide nucleic acids. The oligonucleotides are extremely well suited for splitting a complementary target RNA, the oligonucleotide being released again after the splitting, thus showing a catalytic effect.

IPC 1-7

C07H 21/00; C12Q 1/68

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 41/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6816 (2018.01)

CPC (source: EP)

A61K 41/0042 (2013.01); A61P 31/12 (2017.12); A61P 35/00 (2017.12); C12Q 1/6816 (2013.01)

Citation (search report)

See references of WO 9607667A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9607667 A1 19960314; AU 3519095 A 19960327; CA 2197785 A1 19960314; EP 0778845 A1 19970618; FI 970696 A0 19970219; FI 970696 A 19970219; HU T77034 A 19980302; JP H10505353 A 19980526; NO 970885 D0 19970227; NO 970885 L 19970425

DOCDB simple family (application)

EP 9503408 W 19950830; AU 3519095 A 19950830; CA 2197785 A 19950830; EP 95931942 A 19950830; FI 970696 A 19970219; HU 9701971 A 19950830; JP 50917396 A 19950830; NO 970885 A 19970227