EP 0782582 A1 19970709 - EPIMERS OF (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5-g(a)-ANDROST-1-ENE-17-g(b)-CARBOXAMIDE

Title (en)

EPIMERS OF (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5-g(a)-ANDROST-1-ENE-17-g(b)-CARBOXAMIDE

Title (de)

EPIMER VON (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5-ALPHA-ANDROST-1-ENE-17-BETA-CARBOXAMIDE

Title (fr)

EPIMERES DE (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-Y-YL)-3-OXO-4-AZA-5-g(a)-ANDROST-1-ENE-17-g(b)-CARBOXAMIDE

Publication

EP 0782582 A1 19970709 (EN)

Application

EP 96923968 A 19960628

Priority

EP 9602830 W 19960628
IT MI951587 A 19950721

Abstract (en)

[origin: WO9704002A1] The present invention relates to the epimers: (22R)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5 alpha -androst-1-ene-17 beta -carboxamide and (22S)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5 alpha -androst-1-ene-17 beta -carboxamide useful as inhibitors of testosterone 5 alpha -reductase enzyme, to a process for their preparation and to pharmaceutical compositions containing them.

IPC 1-7

C07J 73/00; A61K 31/58

IPC 8 full level

A61K 31/58 (2006.01); A61P 43/00 (2006.01); C07J 73/00 (2006.01)

CPC (source: EP KR)

A61K 31/58 (2013.01 - KR); A61P 43/00 (2017.12 - EP); C07J 73/00 (2013.01 - KR); C07J 73/005 (2013.01 - EP)

Citation (search report)

See references of WO 9704002A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family (publication)

WO 9704002 A1 19970206; AR 003967 A1 19980930; AU 6418396 A 19970218; BR 9606527 A 19971223; CA 2199273 A1 19970206; CN 1159195 A 19970910; EA 199700045 A1 19971230; EP 0782582 A1 19970709; HU P9702465 A2 19980528; HU P9702465 A3 19981130; IL 120343 A0 19970610; IT 1275594 B1 19970806; IT MI951587 A0 19950721; IT MI951587 A1 19970121; JP H10506411 A 19980623; KR 970706298 A 19971103; MX 9701948 A 19970628; NO 971196 D0 19970314; NO 971196 L 19970314; PL 319351 A1 19970804; ZA 965678 B 19970124

DOCDB simple family (application)

EP 9602830 W 19960628; AR 10365296 A 19960719; AU 6418396 A 19960628; BR 9606527 A 19960628; CA 2199273 A 19960628; CN 96190785 A 19960628; EA 199700045 A 19970418; EP 96923968 A 19960628; HU P9702465 A 19960628; IL 12034396 A 19960628; IT MI951587 A 19950721; JP 50621797 A 19960628; KR 19970701797 A 19970320; MX 9701948 A 19960628; NO 971196 A 19970314; PL 31935196 A 19960628; ZA 965678 A 19960704