EP 0784984 A2 19970723 - Transfection competent molecules
Title (en)
Transfection competent molecules
Title (de)
Transfektion kompetenter Molekülen
Title (fr)
Molécules compétentes à la transfection
Publication
Application
Priority
- EP 97100208 A 19970109
- EP 96100603 A 19960117
Abstract (en)
The invention relates to conjugates of lipids and basic, membrane disturbing peptides. particularly compounds of the formulae (R-CONH)n-R<3> and (R-S-S)n-R<3> wherein R is the hydrocarbyl moiety of a straight-chain or branched-chain, saturated or unsaturated aliphatic carboxylic acid, or a phospholipid moiety having a free valence bond; R<3> is a basic membrane disturbing peptide having a free valence bond at one or two carbon atom(s); and n is 1 or 2. which can be used as a vector for transfecting a cell with a polynucleotide or any other anionic macromolecule.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 47/48 (2006.01)
CPC (source: EP)
A61K 9/1271 (2013.01); A61K 47/544 (2017.07); A61K 47/645 (2017.07)
Citation (applicant)
- FELGNER ET AL., PROC. NATL. ACAD. SCI. USA., vol. 84, 1987, pages 7413 - 7417
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual.", 1989, COLD SPRING HARBOR.
- ZAMECNIC ET AL., PROC. NATL. ACAD. SCI. USA., vol. 75, 1978, pages 280 - 284
- SABERWAL G., NAGARAJ R., BIOCHIM. BIOPHYS. ACTA., vol. 1197, 1994, pages 109 - 131
- BIOCHIM. BIOPHYS. ACTA., vol. 862, 1986, pages 435 - 439
- BEHR J.B., BIOCONJUGATE CHEM., vol. 5, 1994, pages 382 - 389
- GAO X., HUANG L., GENE THER., vol. 2, 1995, pages 710 - 722
- KABANOV A.V., KABANOV V.A., BIOCONJUGATE CHEM., vol. 6, 1995, pages 7 - 20
- LEDLEY F.D., HUMAN GENE THERAPY., vol. 6, 1995, pages 1129 - 1144
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
EP 0784984 A2 19970723; EP 0784984 A3 19990224; EP 0784984 B1 20030702
DOCDB simple family (application)
EP 97100208 A 19970109