EP 0787143 A2 19970806 - PHENYL PEPTIDES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID PEPTIDES
Title (en)
PHENYL PEPTIDES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID PEPTIDES
Title (de)
PHENYLPEPTIDE, HERSTELLUNGSMETHODE UND DIESE PEPTIDE ENTHALTENDE ARZNEI
Title (fr)
PEPTIDES PHENYLES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI EN RENFERMENT
Publication
Application
Priority
- FR 9601008 W 19960628
- FR 9507817 A 19950629
Abstract (en)
[origin: US5844078A] PCT No. PCT/FR96/01008 Sec. 371 Date Feb. 26, 1997 Sec. 102(e) Date Feb. 26, 1997 PCT Filed Jun. 28, 1996 PCT Pub. No. WO97/01576 PCT Pub. Date Jan. 16, 1997The present invention relates to synthetic peptides containing as least nine amino acids of formula (I): <IMAGE> (I) in which X and Y are protected or unprotected amino acid residues, or peptides R is a linear or branched alkyl radical R'' is one of the following radicals: alkyl, phenyl, halogen, nitro, amino, alkyl amino, alkoxy, trifluoromethyl, trifluoromethoxy, carboxamido or cyano Z is a sulphur, an oxygen, an amino or a sulphoxide and n is equal to 0, 1, 2 or 3. The compounds of formula I are inhibitors of HIV replication by acting as inhibitors of a small aspartyl-protease dimer which specifically cleaves the precursors of a polyprotein coding for the structural proteins and the constitutive enzymes of the HIV virus.
IPC 1-7
IPC 8 full level
A61K 38/55 (2006.01); C12N 9/99 (2006.01); A61P 31/12 (2006.01); A61P 43/00 (2006.01); C07K 5/06 (2006.01); C07K 7/06 (2006.01); C07K 14/16 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR US)
A61K 38/55 (2013.01 - KR); A61P 31/12 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 5/06043 (2013.01 - EP US); C07K 14/005 (2013.01 - EP US); C07K 14/16 (2013.01 - KR); A61K 38/00 (2013.01 - EP US); C12N 2740/16222 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
US 5844078 A 19981201; AP 683 A 19980930; AP 9700964 A0 19970430; AU 6462496 A 19970130; AU 706799 B2 19990624; BR 9606455 A 19980714; CA 2197861 A1 19970116; CN 1165521 A 19971119; EP 0787143 A2 19970806; FR 2736055 A1 19970103; FR 2736055 B1 19970912; HU P9701940 A2 19980302; HU P9701940 A3 20010730; IL 120341 A0 19970610; IL 120341 A 20010128; JP H10505613 A 19980602; KR 970705576 A 19971009; NO 970895 D0 19970227; NO 970895 L 19970227; NZ 312726 A 19980728; OA 10403 A 20011205; PL 318880 A1 19970707; WO 9701576 A2 19970116; WO 9701576 A3 19970515
DOCDB simple family (application)
US 79364797 A 19970226; AP 9700964 A 19960628; AU 6462496 A 19960628; BR 9606455 A 19960628; CA 2197861 A 19960628; CN 96190943 A 19960628; EP 96924035 A 19960628; FR 9507817 A 19950629; FR 9601008 W 19960628; HU P9701940 A 19960628; IL 12034196 A 19960628; JP 50421297 A 19960628; KR 19970701333 A 19970228; NO 970895 A 19970227; NZ 31272696 A 19960628; OA 60971 A 19970228; PL 31888096 A 19960628