EP 0787147 A1 19970806 - COMPOSITIONS AND TREATMENT FOR MULTIPLE SCLEROSIS
Title (en)
COMPOSITIONS AND TREATMENT FOR MULTIPLE SCLEROSIS
Title (de)
ZHUSAMMENSETZUNG UND BEHANDLUNG VON MULTISKLEROSE
Title (fr)
COMPOSITIONS ET TRAITEMENT POUR LA SCLEROSE EN PLAQUES
Publication
Application
Priority
- US 9513682 W 19951025
- US 32822494 A 19941025
- US 40422895 A 19950315
Abstract (en)
[origin: WO9612737A2] The present invention provides isolated peptides and combinations of peptides derived form myelin autoantigens such as MBP, MOG, PLP, and MAG suitable for treating multiple sclerosis, including prophylactic and therapeutic compositions and methods for preventing or treating multiple sclerosis. Preferred compositions of the invention comprise at least one isolated, purified peptide, free from all other polypeptides or contaminants, the peptide comprising an amino acid sequence, the myelin autoantigen which has T cell activity. A therapeutic composition of the invention is capable of down regulating the autoantigen specific immune response to the myelin autoantigen in a population of humans suffering from, or susceptible to multiple sclerosis, such that disease symptoms are reduced, eliminated, or reversed and/or the onset or progression of disease symptoms is prevented or slowed. Additionally, compositions and methods of the instant invention when administered in an advanced stage of disease, reverse ongoing paralysis or other signs of disease when administered during the acute phase of disease or prevents relapse when administered during remission.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/21 (2006.01); A61K 39/00 (2006.01); A61P 25/00 (2006.01); A61P 37/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01)
IPC 8 main group level
C07K 7/00 (2006.01)
IPC 8 main group level
A61K (2006.01); C07K (2006.01); C08H (2006.01); C12N (2006.01)
CPC (source: EP)
A61K 38/215 (2013.01); A61P 25/00 (2017.12); A61P 37/00 (2017.12); C07K 14/4713 (2013.01); C07K 14/70503 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9612737 A2 19960502; WO 9612737 A3 19961010; AU 4278296 A 19960515; BR 9509438 A 19971223; CA 2203629 A1 19960502; CZ 122697 A3 19970917; EP 0787147 A1 19970806; FI 971750 A0 19970424; FI 971750 A 19970624; HU T77047 A 19980302; IL 115766 A0 19960119; IS 4466 A 19970417; JP H10504039 A 19980414; NO 971900 D0 19970424; NO 971900 L 19970625; PL 324091 A1 19980511; SI 9520118 A 19980831; SK 51297 A3 19980304
DOCDB simple family (application)
US 9513682 W 19951025; AU 4278296 A 19951025; BR 9509438 A 19951025; CA 2203629 A 19951025; CZ 122697 A 19951025; EP 95941330 A 19951025; FI 971750 A 19970424; HU 9701843 A 19951025; IL 11576695 A 19951025; IS 4466 A 19970417; JP 51410996 A 19951025; NO 971900 A 19970424; PL 32409195 A 19951025; SI 9520118 A 19951025; SK 51297 A 19951025